Sellers E M, Hamilton C A, Kaplan H L, Degani N C, Foltz R L
Br J Clin Pharmacol. 1985 Mar;19(3):398-401. doi: 10.1111/j.1365-2125.1985.tb02660.x.
In order to study the effects of ethanol on the pharmacokinetics of propoxyphene, six healthy male volunteers were each given (1) propoxyphene 65 mg p.o. preceded by 1 h by ethanol 0.9 g/kg lean body weight and followed for 7.5 h by ethanol dosed to maintain breath ethanol at 800-1000 mg/l; and (2) propoxyphene 65 mg p.o. with orange juice in the same volume and frequency as ethanol. Ethanol did not induce any significant changes in apparent t 1/2 or Cmax of propoxyphene or norpropoxyphene. The average norpropoxyphene/propoxyphene ratio decreased by a mean 36%.
为研究乙醇对丙氧芬药代动力学的影响，对6名健康男性志愿者分别给予：(1)在口服65 mg丙氧芬前1小时，按0.9 g/kg瘦体重给予乙醇，随后7.5小时内持续给予乙醇以使呼气乙醇浓度维持在800 - 1000 mg/l；(2)口服65 mg丙氧芬，同时给予与乙醇相同体积和频率的橙汁。乙醇未引起丙氧芬或去甲丙氧芬的表观t1/2或Cmax发生任何显著变化。去甲丙氧芬/丙氧芬的平均比值下降了36%。
