Edwards D J, Babiak L M, Beckman H B
Eur J Clin Pharmacol. 1987;32(5):481-4. doi: 10.1007/BF00637674.
The magnitude and time course of changes in hepatic blood flow following oral ingestion of a single (0.6 g/kg) dose of ethanol was studied using the model compound indocyanine green (ICG). Hepatic blood flow was not significantly different at 40, 90, 150 and 210 minutes following ethanol as compared to baseline values measured 20 and 70 min prior to alcohol ingestion. These results suggest that ethanol, at concentrations commonly associated with social drinking, has minimal effects on liver blood flow and would be expected to contribute little to changes in either the bioavailability or clearance of drugs highly extracted by the liver.
使用模型化合物吲哚菁绿（ICG）研究了口服单剂量（0.6 g/kg）乙醇后肝血流变化的幅度和时间进程。与饮酒前20分钟和70分钟测得的基线值相比，乙醇摄入后40、90、150和210分钟时肝血流无显著差异。这些结果表明，在通常与社交饮酒相关的浓度下，乙醇对肝血流影响极小，预计对肝脏高摄取药物的生物利用度或清除率变化影响不大。
