Nizam Aifa Asyhira Khairul, Masri Syafira, Fadilah Nur Izzah Md, Maarof Manira, Fauzi Mh Busra
Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Advance Bioactive Materials-Cells UKM Research Group, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia.
Pharmaceuticals (Basel). 2025 Jan 7;18(1):58. doi: 10.3390/ph18010058.
Chronic wounds present a substantial healthcare obstacle, marked by an extended healing period that can persist for weeks, months, or even years. Typically, they do not progress through the usual phases of healing, which include hemostasis, inflammation, proliferation, and remodeling, within the expected timeframe. Therefore, to address the socioeconomic burden in taking care of chronic wounds, hydrogel-based therapeutic materials have been proposed. Hydrogels are hydrophilic polymer networks with a 3D structure which allows them to become skin substitutes for chronic wounds. Knowing that peptides are abundant in the human body and possess distinct biological functionality, activity, and selectivity, their adaptability as peptide-based hydrogels to individual therapeutic requirements has made them a significant potential biomaterial for the treatment of chronic wounds. Peptide-based hydrogels possess excellent physicochemical and mechanical characteristics such as biodegradability and swelling, and suitable rheological properties as well great biocompatibility. Moreover, they interact with cells, promoting adhesion, migration, and proliferation. These characteristics and cellular interactions have driven peptide-based hydrogels to be applied in chronic wound healing.
慢性伤口是一个重大的医疗保健障碍，其特征是愈合期延长，可持续数周、数月甚至数年。通常情况下，它们不会在预期的时间内经历愈合的通常阶段，包括止血、炎症、增殖和重塑。因此，为了解决照顾慢性伤口所带来的社会经济负担，人们提出了基于水凝胶的治疗材料。水凝胶是具有三维结构的亲水性聚合物网络，这使得它们能够成为慢性伤口的皮肤替代品。鉴于肽在人体中含量丰富且具有独特的生物学功能、活性和选择性，基于肽的水凝胶对个体治疗需求的适应性使其成为治疗慢性伤口的一种极具潜力的生物材料。基于肽的水凝胶具有优异的物理化学和机械特性，如生物可降解性和膨胀性，以及合适的流变学特性和良好的生物相容性。此外，它们与细胞相互作用，促进细胞黏附、迁移和增殖。这些特性以及与细胞的相互作用推动了基于肽的水凝胶在慢性伤口愈合中的应用。
