Flynn Kiley, Mahmoud Nouf N, Sharifi Shahriar, Gould Lisa J, Mahmoudi Morteza
Department of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824-1312, United States.
Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
ACS Pharmacol Transl Sci. 2023 Apr 19;6(5):783-801. doi: 10.1021/acsptsci.3c00030. eCollection 2023 May 12.
In this paper, we review and analyze the commonly available wound healing models reported in the literature and discuss their advantages and issues, considering their relevance and translational potential to humans. Our analysis includes different in vitro and in silico as well as in vivo models and experimental techniques. We further explore the new technologies in the study of wound healing to provide an all encompassing review of the most efficient ways to proceed with wound healing experiments. We revealed that there is not one model of wound healing that is superior and can give translatable results to human research. Rather, there are many different models that have specific uses for studying certain processes or stages of wound healing. Our analysis suggests that when performing an experiment to assess stages of wound healing or different therapies to enhance healing, one must consider not only the species that will be used but also the type of model and how this can best replicate the physiology or pathophysiology in humans.
在本文中，我们回顾并分析了文献中报道的常用伤口愈合模型，讨论了它们的优点和问题，同时考虑了它们与人类的相关性和转化潜力。我们的分析包括不同的体外、计算机模拟以及体内模型和实验技术。我们进一步探索了伤口愈合研究中的新技术，以全面综述进行伤口愈合实验的最有效方法。我们发现，没有一种伤口愈合模型是优越的，能够为人类研究提供可转化的结果。相反，有许多不同的模型在研究伤口愈合的某些过程或阶段时有特定用途。我们的分析表明，在进行评估伤口愈合阶段或不同促进愈合疗法的实验时，不仅必须考虑将使用的物种，还必须考虑模型的类型以及它如何最好地复制人类的生理学或病理生理学。
