凝血酶可增强洗涤后的人血小板与胶原蛋白的黏附作用。
Thrombin increases the adhesion of washed human platelets to collagen.
作者信息
Sinigaglia F, Balduini C L, Bisio A, Balduini C
出版信息
Br J Haematol. 1985 Apr;59(4):587-92. doi: 10.1111/j.1365-2141.1985.tb07352.x.
Thrombin stimulates the adhesion of washed human platelets to fibrillar collagen. This phenomenon occurs also when platelets, before thrombin stimulation, are resuspended in the presence of prostaglandin E1 to minimize the release reaction. Enzymatic activity of thrombin is not necessary for the enhancement of platelet adhesiveness, since phenylmethylsulphonylfluoride inhibited thrombin is effective in this respect. Detachment of thrombin from thrombin treated platelets by the use of hirudin restores normal platelet adhesiveness to collagen.
凝血酶刺激洗涤后的人血小板与纤维状胶原黏附。当血小板在凝血酶刺激前于前列腺素E1存在的情况下重悬以尽量减少释放反应时，这种现象也会发生。凝血酶的酶活性对于增强血小板黏附性并非必需，因为苯甲基磺酰氟抑制的凝血酶在这方面是有效的。通过使用水蛭素使凝血酶从经凝血酶处理的血小板上解离，可恢复血小板对胶原的正常黏附性。
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