蛋白质摄入对中国老年人认知功能的影响:一项10年随访研究。
Effects of Protein Intake on Cognitive Function in Chinese Older Adults: A 10-Year Follow-Up Study.
作者信息
Zheng Ting, Zheng Xiao, Xiao Shujuan, Xue Benli, Chen Chengyu, Li Yuyang, Li Xiyan, Zhang Chichen
机构信息
School of Health Management, Southern Medical University, Guangzhou 510515, China.
Key Laboratory of Philosophy and Social Sciences of Colleges and Universities in Guangdong Province for Collaborative Innovation of Health Management Policy and Precision Health Service, Guangzhou 510515, China.
出版信息
Nutrients. 2025 Jan 13;17(2):272. doi: 10.3390/nu17020272.
BACKGROUND
As the global population ages, there is an increasing prevalence of mild cognitive impairment and dementia. Protecting and preserving cognitive function in older adults has become a critical public health concern.
METHODS
This study utilized data from four phases of the Chinese Longitudinal Healthy Longevity Survey conducted from 2008 to 2018, encompassing a total of 2454 participants. Latent growth curve modeling was employed to analyze the trajectory and role of protein intake frequency and cognitive function.
RESULTS
The frequency of protein intake among older adults tends to rise, with individuals exhibiting higher initial levels experiencing smaller subsequent increases. Conversely, cognitive function generally declines, with those starting at higher levels experiencing more pronounced decreases. Notably, the initial frequency of protein intake is positively correlated with the initial level of cognitive function ( = 0.227, 95% CI: 0.156 to 0.299, < 0.001), but does not significantly influence the rate of change in cognitive function ( = -0.030, 95% CI: -0.068 to 0.009, = 0.128). The rate of change in protein intake frequency is positively associated with the rate of change in cognitive function ( = 0.152, 95% CI: 0.023 to 0.280, = 0.020).
CONCLUSIONS
The alterations in protein intake frequency are linked to alterations in cognitive function among older adults. Maintaining a stable high frequency of protein intake or increasing the frequency of protein intake may contribute to stabilizing cognitive function as well as reducing the risk of cognitive impairment and dementia in older adults.
背景
随着全球人口老龄化,轻度认知障碍和痴呆症的患病率日益上升。保护和维持老年人的认知功能已成为一项关键的公共卫生问题。
方法
本研究利用了2008年至2018年进行的中国健康与养老追踪调查四个阶段的数据,共有2454名参与者。采用潜在增长曲线模型分析蛋白质摄入频率与认知功能的轨迹及作用。
结果
老年人蛋白质摄入频率呈上升趋势,初始水平较高的个体后续增幅较小。相反,认知功能总体呈下降趋势,起始水平较高的个体下降更为明显。值得注意的是,蛋白质摄入的初始频率与认知功能的初始水平呈正相关(=0.227,95%CI:0.156至0.299,<0.001),但对认知功能的变化率无显著影响(= -0.030,95%CI:-0.068至0.009,=0.128)。蛋白质摄入频率的变化率与认知功能的变化率呈正相关(=0.152,95%CI:0.023至0.280,=0.020)。
结论
老年人蛋白质摄入频率的改变与认知功能的改变有关。保持稳定的高蛋白质摄入频率或增加蛋白质摄入频率可能有助于稳定老年人的认知功能,以及降低认知障碍和痴呆症的风险。