Kędzierska Kinga, Dymkowski Marcin, Niegowska Wiktoria, Humięcka Maria, Sawicka Ada, Walczak Iwona, Jędral Zofia Maria, Wąsowski Michał, Bogołowska-Stieblich Agata, Binda Artur, Jaworski Paweł, Tarnowski Wiesław, Jankowski Piotr
Department of Internal Medicine and Geriatric Cardiology, Centre of Postgraduate Medical Education, Orlowski Hospital, 00-416 Warsaw, Poland.
Department of General, Oncological and Bariatric Surgery, Medical Centre of Postgraduate Education, Orlowski Hospital, 00-416 Warsaw, Poland.
Nutrients. 2025 Jan 18;17(2):339. doi: 10.3390/nu17020339.
The long-term follow-up studies investigating the risk of anemia and iron deficiency following bariatric procedures are scarce. This study aimed to determine the influence of body weight reduction and type of bariatric surgery on iron metabolism parameters.
We included 138 consecutive patients who underwent bariatric surgery (120 underwent sleeve gastrectomy and 18 underwent other types of bariatric surgery) between 2010 and 2016. At baseline and at follow-up (median observation: 10 years), examination weight and height were measured, and blood samples for iron metabolism parameters were taken.
Red blood cells (4.75 [4.59-4.96] 10/μL vs. 4.51 [4.25-4.83] 10/μL, < 0.0001), hemoglobin (14.0 [13.3-14.7] g/dL vs. 13.0 [12.1-14.3] g/dL, < 0.0001), and folic acid (7.4 [5.9-10.4] ng/ml vs. 6.0 [4.5-9.1] ng/mL, = 0.01) were significantly lower, while anemia prevalence (6.52% vs. 28.99%, < 0.0001) was significantly higher at the follow-up examination compared to the baseline values. In contrast, iron concentration (86.5 [68.0-109.0] µg/dL vs. 86.5 [55.0-110.0] µg/dL, = 0.42) and TIBC values (351 [326-391] µg/dL vs. 345 [5311-387] µg/dL, = 0.08) did not change significantly. The multivariable regression analyses showed that the only factors independently related to the hemoglobin concentration change were initial hemoglobin concentration, age, and bariatric procedures other than sleeve gastrectomy. Similarly, in the multivariable logistic analysis, the only variables independently related to the risk of anemia were age (adjusted odds ratio 0.93 [95% confidence intervals 0.89-0.97]), initial hemoglobin concentration (0.69 [0.49-0.97]), and procedures other than sleeve gastrectomy bariatric procedures (6.12 [1.86-20.15]).
Age, initial hemoglobin concentration, and type of bariatric procedure but not sex, baseline iron serum level, or weight change are related to the risk of anemia in the long-term follow-up following bariatric surgery.
关于减肥手术后贫血和缺铁风险的长期随访研究较少。本研究旨在确定体重减轻和减肥手术类型对铁代谢参数的影响。
我们纳入了2010年至2016年间连续接受减肥手术的138例患者（120例行袖状胃切除术，18例行其他类型减肥手术）。在基线和随访时（中位观察期：10年），测量体重和身高，并采集血液样本检测铁代谢参数。
随访时红细胞计数（4.75[4.59 - 4.96]×10¹²/μL对4.51[4.25 - 4.83]×10¹²/μL，P < 0.0001）、血红蛋白（14.0[13.3 - 14.7]g/dL对13.0[12.1 - 14.
