Wang Chunxia, Liu Huijuan, Zhang Shuyu, Ren Chengyi, Xu Jiaming, Chen Juanjuan, Chen Haimin, Wu Wei
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo University, Ningbo 315211, China.
Collaborative Innovation Center for Zhejiang Marine High-Efficiency and Healthy Aquaculture, Ningbo University, Ningbo 315211, China.
Nutrients. 2025 Jan 20;17(2):355. doi: 10.3390/nu17020355.
, which are filamentous cyanobacteria, have gained significant popularity in the food industry, medicine, and aquaculture.
In this study, our objective was to explore the influence of on the gut microbiota and exercise capacity of mice undergoing high-intensity exercise. Twenty-four male BALB/c mice were divided into four groups, with six mice in each group. These groups included the control group (Control, in which the mice received saline gavage and were permitted free movement), the exercise group (Running, in which the mice were gavaged with the same volume of saline and subjected to a structured exercise regimen), and the intervention groups (including and ). In the intervention groups, the mice were orally administered with at doses of 100 and 300 mg/kg/day for four weeks while simultaneously participating in the exercise protocol.
The results illustrated that the Running group mice subjected to intense exercise exhibited reduced weight and tension, acute damage to muscle and liver tissues, oxidative stress, and an imbalance in the gut microbiota compared with that of the Control group. However, high-concentration supplementation was found to increase the tensile strength of the exercise mice by 1.27 ± 0.19 fold ( < 0.05) and ameliorate muscle and liver damage. In the group, the levels of certain indicators related to muscle oxidative stress, including reactive oxygen species, total superoxide dismutase, and catalase, were decreased by 39 ± 5.32% ( < 0.01) and increased by 1.11 ± 0.17 fold and 1.19 ± 0.22 fold ( < 0.01) compared to the Running group. Additionally, a correlation analysis reveals that the alterations in gut microbiota induced by might be associated with the indicators of tension and oxidative stress.
Collectively, these findings point to the fact that can effectively mitigate the acute damage to muscles and the liver induced by intense exercise in mice by enhancing antioxidant capacity and regulating the gut microbiota, thereby providing novel insights into the mechanism underlying the enhancement of exercise function.
丝状蓝细菌在食品工业、医学和水产养殖中颇受关注。
本研究旨在探讨[具体物质]对进行高强度运动的小鼠肠道微生物群和运动能力的影响。将24只雄性BALB/c小鼠分为四组，每组6只。这些组包括对照组（Control，小鼠接受生理盐水灌胃并可自由活动）、运动组（Running，小鼠接受相同体积的生理盐水灌胃并进行结构化运动方案）以及[具体物质]干预组（包括[具体物质1]和[具体物质2]）。在[具体物质]干预组中，小鼠以100和300 mg/kg/天的剂量口服[具体物质]四周，同时参与运动方案。
结果表明，与对照组相比，进行剧烈运动的运动组小鼠体重减轻、张力降低，肌肉和肝脏组织受到急性损伤，存在氧化应激，肠道微生物群失衡。然而，发现高浓度补充[具体物质]可使运动小鼠的拉伸强度提高1.27±0.19倍（P<0.05），并改善肌肉和肝脏损伤。在[具体物质1]组中，与运动组相比，某些与肌肉氧化应激相关的指标水平，包括活性氧、总超氧化物歧化酶和过氧化氢酶，分别降低了39±5.32%（P<0.01），并提高了1.11±0.17倍和1.19±0.22倍（P<0.01）。此外，相关性分析表明，[具体物质]引起的肠道微生物群变化可能与张力和氧化应激指标有关。
总体而言，这些发现表明[具体物质]可通过增强抗氧化能力和调节肠道微生物群有效减轻小鼠剧烈运动引起的肌肉和肝脏急性损伤，从而为运动功能增强的潜在机制提供新见解。
