Vignaud Jordi, Loiseau Céline, Côme Martine, Martin Isabelle, Rasoanarivo Rova, Hérault Josiane, Mayer Claire, Lépine Olivier, Ulmann Lionel
BiOSSE, Biology of Organisms, Stress, Health, Environment, Institut Universitaire de Technologie, Département Génie Biologique, Le Mans Université, 53020 Laval, France.
AlgoSource, 44350 Guérande, France.
Nutrients. 2025 Jan 14;17(2):283. doi: 10.3390/nu17020283.
Physical activity, such as running, protects against cardiovascular disease and obesity but can induce oxidative stress. Athletes often consume antioxidants to counteract the overproduction of reactive oxygen and nitrogen species during exercise. , particularly its phycocyanin content, activates the Nrf2 pathway, stimulating antioxidant responses. Studies show that phycocyanin enhances antioxidant defenses and reduces inflammation, potentially improving muscle adaptation and recovery. This study evaluates a liquid extract (SLE) supplementation during endurance training, hypothesizing that phycocyanin improves oxidant status and performance in soleus and extensor digitorum longus muscles.
Three-week-old male Wistar rats were divided into four groups: a sedentary control group (C), a sedentary group supplemented with SLE (SP), an endurance training group (T), and an endurance training group supplemented with SLE (SPT). After 8 weeks of treadmill training, blood and muscle were collected. Biochemical parameters and gene expression analyses were performed to assess the effects of training and supplementation.
The maximal aerobic speed improved significantly in the SPT group. Plasma lipid profiles showed a reduction in triglyceridemia, cholesterolemia, and atherogenic index in the trained groups, especially with SLE supplementation. Muscle malondialdehyde levels decreased in the SPT group compared to T. Gene expression analysis revealed upregulation of Nrf2 and mitochondrial biogenesis genes in both muscles, with differences between groups for genes related to glycogen storage and β-oxidation.
This study demonstrated that SLE supplementation enhanced exercise performance and promoted muscle molecular adaptations. These findings suggest SLE as a promising functional food supplement for athletes, optimizing recovery and performance.
诸如跑步之类的体育活动可预防心血管疾病和肥胖症，但会引发氧化应激。运动员常摄入抗氧化剂以对抗运动过程中活性氧和氮物种的过量产生。 ，尤其是其藻蓝蛋白含量，可激活Nrf2信号通路，刺激抗氧化反应。研究表明，藻蓝蛋白可增强抗氧化防御能力并减轻炎症，可能改善肌肉适应性和恢复能力。本研究评估了在耐力训练期间补充一种液体提取物（SLE）的效果，假设藻蓝蛋白可改善比目鱼肌和趾长伸肌的氧化状态及性能。
将三周龄雄性Wistar大鼠分为四组：久坐对照组（C）、补充SLE的久坐组（SP）、耐力训练组（T）和补充SLE的耐力训练组（SPT）。经过8周的跑步机训练后，采集血液和肌肉样本。进行生化参数和基因表达分析以评估训练和补充的效果。
SPT组的最大有氧速度显著提高。血浆脂质谱显示，训练组的甘油三酯血症、胆固醇血症和动脉粥样硬化指数降低，尤其是补充SLE的组。与T组相比，SPT组的肌肉丙二醛水平降低。基因表达分析显示，两组肌肉中Nrf2和线粒体生物发生基因均上调，与糖原储存和β氧化相关的基因在组间存在差异。
本研究表明，补充SLE可提高运动表现并促进肌肉分子适应性。这些发现表明SLE作为一种有前景的功能性食品补充剂，可优化运动员的恢复和表现。
