Mongalo Nkoana I, Raletsena Maropeng V
College of Agriculture and Environmental Science (CAES), University of South Africa, Priva Bag X06, Florida 0710, South Africa.
Plants (Basel). 2025 Jan 16;14(2):239. doi: 10.3390/plants14020239.
Plants have long been used to treat serious illnesses in both humans and animals. A significant underappreciated medicinal tree, Sond is utilized by many different ethnic groups to cure a wide range of illnesses. A variety of electronic databases, including ScienceDirect, Scopus, Scielo, Scifinder, PubMed, Web of Science, Medline, and Google Scholar, were used to search the literature on , using key words such as uses, survey, pharmacology, antigonococcal, toxicity, phytochemistry and others. Further data was obtained from several scholarly theses, dissertations, and books on general plant sciences, ethnomedicine, and other pertinent ethnobotanical topics. The plant species possess very important pharmacological activities in vitro, which includes antimicrobial, anti-HIV, antioxidant, anticancer, antidiabetic, and other activities. Phytochemically, the plant possesses various classes of compounds, dominated by flavonols, which may well explain its wider range of pharmacological activities. Although the plant is promising anti-HIV activity, the mode of action and safety profiles of the plant also need to be explored as its extracts exerted some degree of mutagenicity. It is also important to further explore its ethnoveterinary use against a plethora of nematodes that infects both wild and domestic animals. Given its potent pharmacological activity, the further in vivo studies need to be explored to ascertain the comprehensive toxicology of the plant species, thereby developing possible medications. The plant species may further be elevated to a potent pharmaceutical product against plethora of infections.
长期以来，植物一直被用于治疗人类和动物的严重疾病。一种未得到充分重视的重要药用树——桑德，被许多不同的族群用于治疗多种疾病。我们使用了多种电子数据库，包括ScienceDirect、Scopus、Scielo、Scifinder、PubMed、Web of Science、Medline和谷歌学术，以“用途”“调查”“药理学”“抗淋球菌”“毒性”“植物化学”等关键词搜索关于桑德的文献。进一步的数据来自几篇关于一般植物科学、民族医学和其他相关民族植物学主题的学术论文、学位论文和书籍。该植物物种在体外具有非常重要的药理活性，包括抗菌、抗艾滋病毒、抗氧化、抗癌、抗糖尿病等活性。从植物化学角度来看，该植物含有各类化合物，其中黄酮醇占主导，这很可能解释了其广泛的药理活性。尽管该植物具有有前景的抗艾滋病毒活性，但由于其提取物具有一定程度的致突变性，其作用方式和安全性也需要探索。进一步探索其在民族兽医学中用于对抗感染野生和家养动物的大量线虫也很重要。鉴于其强大的药理活性，需要进一步进行体内研究以确定该植物物种的全面毒理学，从而开发可能的药物。该植物物种可能会进一步提升为一种针对多种感染的强效药品。
