CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; Sino-Africa Joint Research Center, Chinese Academy of Sciences, Wuhan, 430074, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; Sino-Africa Joint Research Center, Chinese Academy of Sciences, Wuhan, 430074, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Hubei University, Wuhan, 430011, China.
J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117222. doi: 10.1016/j.jep.2023.117222. Epub 2023 Oct 2.
Actinidia Lindl. belongs to the family Actinidiaceae. Plants of this genus are popularly known as kiwifruits and are traditionally used to treat a wide range of ailments associated with digestive disorders, rheumatism, kidney problems, cardiovascular system, cancers, dyspepsia, hemorrhoids, and diabetes among others.
This review discusses the ethnobotanical uses, phytochemical profile, and known pharmacological properties of Actinidia plants, to understand their connotations and provide the scientific basis for future studies.
The data were obtained by surveying journal articles, books, and dissertations using various search engines such as Google Scholar, PubMed, Science Direct, Springer Link, and Web of Science. The online databases; World Flora Online, Plants of the World Online, International Plant Names Index, and Global Biodiversity Information Facility were used to confirm the distribution and validate scientific names of Actinidia plants. The isolated metabolites from these species were illustrated using ChemBio Draw ultra-version 14.0 software.
Ten (10) species of Actinidia genus have been reported as significant sources of traditional medicines utilized to remedy diverse illnesses. Our findings revealed that a total of 873 secondary metabolites belonging to different classes such as terpenoids, phenolic compounds, alcohols, ketones, organic acids, esters, hydrocarbons, and steroids have been isolated from different species of Actinidia. These compounds were mainly related to the exhibited antioxidant, antimicrobial, anti-inflammatory, antidiabetic, antiproliferative, anti-angiogenic, anticinoceptive, anti-tumor, and anticancer activities.
This study assessed the information related to the ethnobotanical uses, phytochemical compounds, and pharmacological properties of Actinidia species, which indicate that they possess diverse bioactive metabolites with interesting bioactivities. Actinidia plants have great potential for applications in folklore medicines and pharmaceuticals due to their wide ethnomedicinal uses and biological activities. Traditional uses of several Actinidia species are supported by scientific evidences, qualifying them as possible modern remedies for various ailments. Nonetheless, the currently available data has several gaps in understanding the herbal utilization of most Actinidia species. Thus, further research into their toxicity, mechanisms of actions of the isolated bioactive metabolites, as well as scientific connotations between the traditional medicinal uses and pharmacological properties is required to unravel their efficacy in therapeutic potential for safe clinical application.
藤黄属植物属于藤黄科。该属植物俗称猕猴桃，传统上用于治疗与消化紊乱、风湿病、肾脏问题、心血管系统、癌症、消化不良、痔疮和糖尿病等相关的多种疾病。
本综述讨论了猕猴桃属植物的民族植物学用途、植物化学特征和已知的药理学特性，以了解它们的含义，并为未来的研究提供科学依据。
通过使用各种搜索引擎（如 Google Scholar、PubMed、Science Direct、Springer Link 和 Web of Science）检索期刊文章、书籍和论文，获得数据。还使用在线数据库，如世界植物名录在线、世界植物名录在线、国际植物命名索引和全球生物多样性信息设施，以确认猕猴桃属植物的分布和验证其科学名称。使用 ChemBio Draw ultra-version 14.0 软件对这些物种中分离出的代谢物进行了说明。
报道了藤黄属的十种（10）种植物是传统药物的重要来源，用于治疗多种疾病。我们的研究结果表明，从不同的猕猴桃物种中分离出了总共 873 种属于萜类、酚类化合物、醇类、酮类、有机酸、酯类、烃类和甾体类等不同类别的次生代谢物。这些化合物主要与抗氧化、抗菌、抗炎、抗糖尿病、抗增殖、抗血管生成、抗惊厥、抗肿瘤和抗癌活性有关。
本研究评估了与猕猴桃属植物的民族植物学用途、植物化学化合物和药理学特性相关的信息，表明它们具有多种具有有趣生物活性的生物活性代谢物。由于其广泛的民族医学用途和生物活性，猕猴桃属植物在民间药物和药物方面具有很大的应用潜力。几种猕猴桃属植物的传统用途得到了科学证据的支持，使它们有资格成为各种疾病的潜在现代治疗方法。然而，目前可用的数据在理解大多数猕猴桃属植物的草药利用方面存在一些差距。因此，需要进一步研究其毒性、分离的生物活性代谢物的作用机制，以及传统药用用途和药理学特性之间的科学内涵，以揭示其在治疗潜力方面的疗效，以确保安全的临床应用。
