Schimmich Cécile, Vabret Astrid, Zientara Stéphan, Valle-Casuso José Carlos
ANSES Animal Health Laboratory, PhEED Unit, 14430 Goustranville, France.
Department of Virology, University of Caen Normandy, Dynamicure INSERM UMR 1311, Centre Hospitalo Universitaire (CHU) Caen, 14000 Caen, France.
Viruses. 2024 Dec 24;17(1):5. doi: 10.3390/v17010005.
Equine infectious anemia virus (EIAV) is the simplest described within the family, related to the human immunodeficiency viruses (HIV-1 and HIV-2). There is an important interplay between host cells and viruses. Viruses need to hijack cellular proteins for their viral cycle completion and some cellular proteins are antiviral agents interfering with viral replication. HIV cellular partners have been extensively studied and described, with a special attention to host proteins able to inhibit specific steps of the viral cycle, called restriction factors. Viruses develop countermeasures against these restriction factors. Here, we aim to describe host cellular protein partners of EIAV viral replication, being proviral or antiviral. A comprehensive vision of the interactions between the virus and specific host's proteins can help with the discovery of new targets for the design of therapeutics. Studies performed on HIV-1 can provide insights into the functioning of EIAV, as well as differences, as both types of virus research can benefit from each other.
马传染性贫血病毒（EIAV）是该科中描述最为简单的病毒，与人类免疫缺陷病毒（HIV-1和HIV-2）相关。宿主细胞与病毒之间存在重要的相互作用。病毒需要劫持细胞蛋白以完成其病毒周期，而一些细胞蛋白是干扰病毒复制的抗病毒因子。HIV的细胞伴侣已得到广泛研究和描述，特别关注能够抑制病毒周期特定步骤的宿主蛋白，即限制因子。病毒会针对这些限制因子制定应对措施。在此，我们旨在描述EIAV病毒复制的宿主细胞蛋白伴侣，包括促进病毒的或抗病毒的。全面了解病毒与特定宿主蛋白之间的相互作用有助于发现治疗药物设计的新靶点。对HIV-1进行的研究可以为EIAV的功能以及两者之间的差异提供见解，因为这两种病毒的研究可以相互受益。
