Hong Xue-Geng, Zhang Mei-Qi, Tang Fang, Song Si-Hui, Wang Jia-Yi, Hu Zhen-Yu, Liu Li-Ming, Zhang Xiao-Ai, Sun Yi, Fang Li-Qun, Liu Wei
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing 100071, China.
The 960th Hospital of the PLA Joint Logistics Support Force, Jinan 250031, China.
Viruses. 2024 Dec 25;17(1):15. doi: 10.3390/v17010015.
Toscana virus (TOSV), a member of the genus transmitted by sandflies, is acknowledged for its capacity to cause neurological infections and is widely distributed across Mediterranean countries. The potential geographic distribution and risk to the human population remained obscure due to its neglected nature. We searched PubMed and Web of Science for articles published between 1 January 1971 and 30 June 2023 to extract data on TOSV detection in vectors, vertebrates and humans, clinical information of human patients, as well as the occurrence of two identified sandfly vectors for TOSV. We further predicted the global distribution of the two sandfly vectors, based on which the global risk of TOSV was projected, after incorporating the environmental, ecoclimatic, biological, and socioeconomic factors. A total of 1342 unique studies were retrieved, among which 389 met the selection criteria and were included for data extraction. TOSV infections were documented in 10 sandfly species and 14 species of vertebrates, as well as causing a total of 7571 human infections. The occurrence probabilities of two sandfly vectors have demonstrated the greatest contributions to the potential distribution of TOSV infection risk. This study provides a comprehensive overview of global TOSV distribution and potential risk zones. Future surveillance and intervention programs should prioritize high-risk areas based on updated quantitative analyses.
托斯卡纳病毒（TOSV）是一种由白蛉传播的病毒属成员，因其具有引发神经感染的能力而为人所知，在地中海国家广泛分布。由于其受忽视的特性，其潜在的地理分布和对人类的风险仍不明确。我们在PubMed和科学网中搜索了1971年1月1日至2023年6月30日期间发表的文章，以提取有关TOSV在媒介、脊椎动物和人类中的检测数据、人类患者的临床信息，以及已确定的两种TOSV白蛉媒介的出现情况。我们进一步预测了这两种白蛉媒介的全球分布，并在此基础上，在纳入环境、生态气候、生物和社会经济因素后，预测了TOSV的全球风险。总共检索到1342项独特研究，其中389项符合选择标准并被纳入数据提取。在10种白蛉物种和14种脊椎动物中记录到TOSV感染，总共导致7571例人类感染。两种白蛉媒介的出现概率对TOSV感染风险的潜在分布贡献最大。本研究全面概述了全球TOSV分布和潜在风险区域。未来的监测和干预计划应根据最新的定量分析，将高风险地区作为优先事项。
