Ma Leping, Liu Cui, Song Ran, Qian Yeping, Zhang Feng
Department of Child Health, Shaoxing Keqiao Maternal and Child Health Care Hospital, 312030 Shaoxing, Zhejiang, China.
Department of Pediatrics, Qingdao Huangdao District Central Hospital, 266555 Qingdao, Shandong, China.
J Integr Neurosci. 2025 Jan 23;24(1):24948. doi: 10.31083/JIN24948.
Autism spectrum disorder (ASD) has been reported to confer an increased risk of natural premature death. Telomere erosion caused by oxidative stress is a common consequence in age-related diseases. However, whether telomere length (TL) and oxidative indicators are significantly changed in ASD patients compared with controls remains controversial. The aim of this study was to determine the associations of ASD with TL and oxidative indicators by performing a meta-analysis of all published evidence.
The PubMed and Embase databases were searched for articles published up to April, 2024. The effect size was expressed as standardized mean difference (SMD) and 95% confidence interval (CI) via Stata 15.0 software.
Thirty-nine studies were included. Pooled results showed that compared with controls, children and adolescents with ASD were associated with significantly shorter TL (SMD = -0.48; 95% CI = -0.66- -0.29; < 0.001; particularly in males), lower total antioxidant capacity (TAC: SMD = -1.15; 95% CI = -2.01- -0.30; = 0.008), and higher oxidative DNA (8-hydroxy-2-deoxyguanosine, 8-OHdG: SMD = 0.63; 95% CI = 0.03-1.23; = 0.039), lipid (hexanolyl-lysine, HEL: SMD = 0.37; 95% CI = 0.13-0.62; = 0.003), and protein (3-nitrotyrosine, 3-NT: SMD = 0.86; 95% CI = 0.21-1.51; = 0.01; dityrosine, DT: SMD = 0.66; 95% CI = 0.521-0.80; < 0.01) damage. There were no significant differences between ASD and controls in 8-isoprostane and oxidative stress index after publication bias correction, and in N-formylkynurenine during overall meta-analysis.
TL, 8-OHdG, TAC, HEL, 3-NT, and DT represent potential biomarkers for prediction of ASD in children and adolescents.
据报道，自闭症谱系障碍（ASD）会增加自然过早死亡的风险。氧化应激导致的端粒侵蚀是与年龄相关疾病的常见后果。然而，与对照组相比，ASD患者的端粒长度（TL）和氧化指标是否有显著变化仍存在争议。本研究的目的是通过对所有已发表证据进行荟萃分析，确定ASD与TL和氧化指标之间的关联。
检索PubMed和Embase数据库中截至2024年4月发表的文章。通过Stata 15.0软件将效应量表示为标准化平均差（SMD）和95%置信区间（CI）。
纳入39项研究。汇总结果显示，与对照组相比，患有ASD的儿童和青少年的TL显著缩短（SMD = -0.48；95%CI = -0.66 - -0.29；P < 0.001；尤其是在男性中），总抗氧化能力较低（TAC：SMD = -1.15；95%CI = -2.01 - -0.30；P = 0.008），氧化DNA（8-羟基-2'-脱氧鸟苷，8-OHdG：SMD = 0.63；95%CI = 0.03 - 1.23；P = 0.039）、脂质（己酰赖氨酸，HEL：SMD = 0.37；95%CI = 0.13 - 0.62；P = 0.003）和蛋白质（3-硝基酪氨酸，3-NT：SMD = 0.86；95%CI = 0.21 - 1.51；P = 0.01；二酪氨酸，DT：SMD = 0.66；95%CI = 0.521 - 0.80；P < 0.01）损伤较高。在发表偏倚校正后，ASD与对照组在8-异前列腺素和氧化应激指数方面以及在总体荟萃分析期间在N-甲酰犬尿氨酸方面没有显著差异。
TL、8-OHdG、TAC、HEL、3-NT和DT代表了预测儿童和青少年ASD的潜在生物标志物。
