Li Jiang-Juan, Li Xin-Ping, Han Jia-Min, Sun Yi-Fan, Liu Xiao-Hong, Gao Xue-Zheng, Chen Li-Min, Zhou Zhen-He, Zhou Hong-Liang
Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, 214151 Wuxi, Jiangsu, China.
Department of Psychology, Wuxi Mental Health Center, Training Base of Hubei University of Medicine, 442000 Shiyan, Hubei, China.
J Integr Neurosci. 2025 Jan 21;24(1):25427. doi: 10.31083/JIN25427.
Deficits in emotion recognition have been shown to be closely related to social-cognitive functioning in schizophrenic. This study aimed to investigate the event-related potential (ERP) characteristics of social perception in schizophrenia patients and to explore the neural mechanisms underlying these abnormal cognitive processes related to social perception.
Participants included 33 schizophrenia patients and 35 healthy controls (HCs). All participants underwent electroencephalogram recording while completing the Emotion Intensity Recognition Task (EIRT). Behavioral data and ERP components were analyzed using repeated measures analysis of variance.
Schizophrenia patients had longer reaction times (RTs) to sad faces compared with disgusted faces, and had lower accuracy than the HCs. Additionally, schizophrenia patients had lower accuracy than the HCs for disgusted faces, surprised faces, angry faces, and fearful faces. Late Positive Potential (LPP) mean amplitudes of the HCs were larger than the schizophrenia patients for sad faces in the frontal lobe and central lobe. For happy faces, the HCs elicited larger LPP mean amplitudes than schizophrenia patients in the frontal lobe and central lobe. For surprised faces, the LPP mean amplitudes were higher in the HCs in the central lobe and parietal lobe than in schizophrenia patients. The HCs exhibited larger LPP mean amplitudes for angry faces in the frontal lobe, central lobe, and parietal lobe than in schizophrenia patients. For fearful faces, the HCs elicited a larger LPP mean amplitude than schizophrenia patients in the frontal lobe, central lobe, and parietal lobe.
Schizophrenia patients present impaired social perception, and the observed ERP patterns provide valuable insights into the neural mechanisms underlying the EIRT results, highlighting the differences between HCs and schizophrenia patients. These findings underscore the potential of the EIRT as a biomarker for cognitive and emotional dysregulation in schizophrenia.
No: ChiCTR2300078149. Registered 29 November, 2023; https://www.chictr.org.cn/showproj.html?proj=211510.
情绪识别缺陷已被证明与精神分裂症患者的社会认知功能密切相关。本研究旨在调查精神分裂症患者社会认知的事件相关电位（ERP）特征，并探索这些与社会认知相关的异常认知过程的神经机制。
参与者包括33名精神分裂症患者和35名健康对照者（HCs）。所有参与者在完成情绪强度识别任务（EIRT）时进行脑电图记录。使用重复测量方差分析对行为数据和ERP成分进行分析。
与厌恶面孔相比，精神分裂症患者对悲伤面孔的反应时间更长，且准确性低于健康对照者。此外，精神分裂症患者对厌恶面孔、惊讶面孔、愤怒面孔和恐惧面孔的准确性低于健康对照者。在额叶和中央叶，健康对照者对悲伤面孔的晚期正电位（LPP）平均波幅大于精神分裂症患者。对于快乐面孔，健康对照者在额叶和中央叶诱发的LPP平均波幅大于精神分裂症患者。对于惊讶面孔，健康对照者在中央叶和顶叶的LPP平均波幅高于精神分裂症患者。健康对照者在额叶、中央叶和顶叶对愤怒面孔诱发的LPP平均波幅大于精神分裂症患者。对于恐惧面孔，健康对照者在额叶、中央叶和顶叶诱发的LPP平均波幅大于精神分裂症患者。
精神分裂症患者存在社会认知受损，观察到的ERP模式为EIRT结果的神经机制提供了有价值的见解，突出了健康对照者与精神分裂症患者之间的差异。这些发现强调了EIRT作为精神分裂症认知和情绪失调生物标志物的潜力。
编号：ChiCTR2300078149。于2023年11月29日注册；https://www.chictr.org.cn/showproj.html?proj=211510。
