Jian Junjie, Wei Jun
The First College of Clinical Medical Science, China Three Gorges University, 443000 Yichang, Hubei, China.
Department of Neurology, Yichang Central People's Hospital, 443003 Yichang, Hubei, China.
Front Biosci (Landmark Ed). 2025 Jan 6;30(1):26265. doi: 10.31083/FBL26265.
Multiple sclerosis (MS) is a chronic autoimmune disorder marked by neuroinflammation, demyelination, and neuronal damage. Recent advancements highlight a novel interaction between iron-dependent cell death, known as ferroptosis, and gut microbiota, which may significantly influences the pathophysiology of MS. Ferroptosis, driven by lipid peroxidation and tightly linked to iron metabolism, is a pivotal contributor to the oxidative stress observed in MS. Concurrently, the gut microbiota, known to affect systemic immunity and neurological health, emerges as an important regulator of iron homeostasis and inflammatory responses, thereby influencing ferroptotic pathways. This review investigates how gut microbiota dysbiosis and ferroptosis impact MS, emphasizing their potential as therapeutic targets. Through an integrated examination of mechanistic pathways and clinical evidence, we discuss how targeting these interactions could lead to novel interventions that not only modulate disease progression but also offer personalized treatment strategies based on gut microbiota profiling. This synthesis aims at deepening insights into the microbial contributions to ferroptosis and their implications in MS, setting the stage for future research and therapeutic exploration.
多发性硬化症（MS）是一种慢性自身免疫性疾病，其特征为神经炎症、脱髓鞘和神经元损伤。最近的进展突出了铁依赖性细胞死亡（即铁死亡）与肠道微生物群之间的一种新的相互作用，这可能会显著影响MS的病理生理学。由脂质过氧化驱动并与铁代谢紧密相关的铁死亡，是MS中观察到的氧化应激的关键促成因素。同时，已知会影响全身免疫和神经健康的肠道微生物群，成为铁稳态和炎症反应的重要调节因子，从而影响铁死亡途径。本综述研究了肠道微生物群失调和铁死亡如何影响MS，强调了它们作为治疗靶点的潜力。通过对机制途径和临床证据的综合研究，我们讨论了针对这些相互作用如何能带来新的干预措施，这些措施不仅能调节疾病进展，还能基于肠道微生物群分析提供个性化治疗策略。本综述旨在加深对微生物对铁死亡的贡献及其在MS中的意义的理解，为未来的研究和治疗探索奠定基础。
