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Design, synthesis and cytotoxic activity of sulfonylated derivatives of camptothecin.喜树碱磺酰化衍生物的设计、合成及细胞毒性活性
Nat Prod Res. 2024 Aug 18:1-10. doi: 10.1080/14786419.2024.2392739.
2
Discovery of novel HER2 targeting peptide-camptothecin conjugates with effective suppression for selective cancer treatment.发现新型 HER2 靶向肽-喜树碱缀合物，有效抑制选择性癌症治疗。
Bioorg Chem. 2024 Jun;147:107371. doi: 10.1016/j.bioorg.2024.107371. Epub 2024 Apr 15.
3
20-esterification of 5-spiro CPT and their anticancer activity in vitro.5-螺环喜树碱的20-酯化反应及其体外抗癌活性
Nat Prod Res. 2024 Apr 8:1-9. doi: 10.1080/14786419.2024.2337115.
4
Unleashing the Potential of Camptothecin: Exploring Innovative Strategies for Structural Modification and Therapeutic Advancements.释放喜树碱的潜力：探索结构修饰与治疗学发展的创新策略。
J Med Chem. 2024 Mar 14;67(5):3244-3273. doi: 10.1021/acs.jmedchem.3c02115. Epub 2024 Feb 29.
5
Design and Evaluation of ZD06519, a Novel Camptothecin Payload for Antibody Drug Conjugates.ZD06519 的设计与评估：一种新型喜树碱类药物载体用于抗体偶联药物。
Mol Cancer Ther. 2024 May 2;23(5):606-618. doi: 10.1158/1535-7163.MCT-23-0822.
6
Camptothecin structure simplification elaborated new imidazo[2,1-b]quinazoline derivative as a human topoisomerase I inhibitor with efficacy against bone cancer cells and colon adenocarcinoma.喜树碱结构简化得到新型咪唑并[2,1-b]喹唑啉衍生物，作为一种人拓扑异构酶 I 抑制剂，对骨肉瘤细胞和结肠腺癌细胞具有疗效。
Eur J Med Chem. 2024 Feb 5;265:116049. doi: 10.1016/j.ejmech.2023.116049. Epub 2023 Dec 16.
7
Synthesis and biological evaluation of novel quaternary ammonium antibody drug conjugates based on camptothecin derivatives.基于喜树碱衍生物的新型季铵抗体药物偶联物的合成与生物学评价。
PLoS One. 2023 Dec 19;18(12):e0292871. doi: 10.1371/journal.pone.0292871. eCollection 2023.
8
Design, synthesis and bioactivity evaluation of novel fusion peptides and their CPT conjugates inducing effective anti-tumor responses on HER2 positive tumors.设计、合成新型融合肽及其 CPT 缀合物，并评估其在 HER2 阳性肿瘤上诱导有效抗肿瘤反应的活性。
Eur J Med Chem. 2024 Jan 15;264:116032. doi: 10.1016/j.ejmech.2023.116032. Epub 2023 Dec 7.
9
Stimulus-Responsive Nano-Prodrug Strategies for Cancer Therapy: A Focus on Camptothecin Delivery.刺激响应型纳米前药策略用于癌症治疗：以喜树碱递药为重点。
Small Methods. 2024 Aug;8(8):e2301271. doi: 10.1002/smtd.202301271. Epub 2023 Dec 12.
10
New benzothienopyran and benzothienopyranopyrimidine derivatives as topoisomerase I inhibitors: Design, synthesis, anticancer screening, apoptosis induction and molecular modeling studies.新型苯并噻喃并苯并嘧啶衍生物作为拓扑异构酶 I 抑制剂的设计、合成、抗癌筛选、凋亡诱导及分子模拟研究。
Bioorg Chem. 2023 Aug;137:106638. doi: 10.1016/j.bioorg.2023.106638. Epub 2023 May 27.

Camptothecin: a key building block in the design of anti-tumor agents.

作者信息

Liu Bowen, Yao Lei

机构信息

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Yantai University, Yantai, China.

Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System, Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China.

出版信息

Future Med Chem. 2025 Feb;17(4):381-384. doi: 10.1080/17568919.2025.2458455. Epub 2025 Jan 25.

DOI:10.1080/17568919.2025.2458455
PMID:39862114
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11834417/
Abstract
摘要