Weatherill P J, Bell P A
Biochim Biophys Acta. 1985 May 8;839(3):228-32. doi: 10.1016/0304-4165(85)90002-9.
The glucocorticoid hormone-receptor complex has been shown to exist in several forms. The transformation status of various forms of the complex isolated from rat thymus cytosol in the presence of molybdate was determined. The non-transformed receptor had a higher affinity for DEAE-cellulose than the transformed receptor. The rate at which the non-transformed complex was transformed to a smaller form with a low affinity for DEAE-cellulose by exposure to salt was greater in the absence of molybdate than in its presence. We conclude that salt-induced transformation of the complex is retarded but not prevented by molybdate and is associated with subunit dissociation.
糖皮质激素激素-受体复合物已被证明以几种形式存在。测定了在钼酸盐存在下从大鼠胸腺细胞质中分离出的各种形式复合物的转化状态。未转化的受体对二乙氨基乙基纤维素（DEAE-纤维素）的亲和力高于转化后的受体。在没有钼酸盐的情况下，未转化的复合物通过暴露于盐而转化为对DEAE-纤维素亲和力低的较小形式的速率比有钼酸盐时更快。我们得出结论，钼酸盐会延迟但不会阻止复合物的盐诱导转化，并且这种转化与亚基解离有关。
