Ma Yating, Bai Lijun, Jiang Yunxing, Wang Jinxi, Wei Chen, Li Yinxiang, Tian Yumei, Wu Shaowei
Institute of Social Psychology, School of Humanities and Social Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, China; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an, Shaanxi, China; Key Laboratory of Trace Elements and Endemic Diseases in Ministry of Health, Xi'an, Shaanxi, China.
Schizophr Res. 2025 Feb;276:79-87. doi: 10.1016/j.schres.2025.01.004. Epub 2025 Jan 24.
To investigate the association between ambient coarse particulate matter (PM) pollution and risk of acute schizophrenia episodes.
A time-stratified case-crossover study with a two-stage analytical approach was conducted to investigate the association between ambient PM pollution and schizophrenia admissions (an indicator for acute schizophrenia episodes) across 259 Chinese cities of prefecture-level or above during 2013-2017. A conditional logistic regression model was constructed to estimate city-specific changes in hospital admissions for schizophrenia associated with per interquartile range (IQR) increase in ambient PM, and the overall associations were obtained by pooling the city-specific associations using the random-effects model.
A total of 817,296 schizophrenia admissions were included in the analysis. Per IQR increase (28.43 μg/m) in PM at lag01 was associated with an increase of 1.66 % (95 % CI: 0.68 %, 2.65 %) in schizophrenia admissions. Compared to concentrations <30 μg/m, PM concentrations of 30-49 μg/m and ≥50 μg/m were associated with increases of 2.25 % (95 % CI: 0.73 %%, 3.79 %) and 4.03 % (95 % CI: 1.92 %, 6.18 %) in schizophrenia admissions, respectively. City-level urbanization has the potential to attenuate the association between ambient PM and schizophrenia admissions (P = 0.0002).
Our study provides novel evidence for the acute adverse effects of ambient PM on schizophrenia and calls for special attention on the control of high PM pollution in disease prevention.
探讨环境粗颗粒物（PM）污染与急性精神分裂症发作风险之间的关联。
采用两阶段分析方法进行时间分层病例交叉研究，以调查2013 - 2017年期间中国259个地级及以上城市环境PM污染与精神分裂症入院（急性精神分裂症发作的指标）之间的关联。构建条件逻辑回归模型，以估计环境PM每增加一个四分位数间距（IQR）与精神分裂症住院人数的城市特定变化，并使用随机效应模型汇总城市特定关联以获得总体关联。
分析共纳入817,296例精神分裂症入院病例。滞后01期PM每增加一个IQR（28.43μg/m）与精神分裂症入院人数增加1.66%（95%CI：0.68%，2.65%）相关。与浓度<30μg/m相比，PM浓度为30 - 49μg/m和≥50μg/m分别与精神分裂症入院人数增加2.25%（95%CI：0.73%，3.79%）和4.03%（95%CI：1.92%，6.18%）相关。城市层面的城市化有可能减弱环境PM与精神分裂症入院之间的关联（P = 0.0002）。
我们的研究为环境PM对精神分裂症的急性不良影响提供了新证据，并呼吁在疾病预防中特别关注高PM污染的控制。
