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作者信息

Balla Tamas, Gulyas Gergo

机构信息

Section on Molecular Signal Transduction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Cell Calcium. 2025 Mar;126:102999. doi: 10.1016/j.ceca.2025.102999. Epub 2025 Jan 22.

DOI:10.1016/j.ceca.2025.102999

PMID:39862449

Abstract

Membrane contact sites (MCS) are specialized compartments found in all eukaryotic cells that are formed between membranes of different organelles that are in close proximity. MCS have important functions as they are sites of efficient transfer of molecules between neighboring organelles. Two recent articles have used the splitFAST system to mark and follow the dynamics of membrane contact sites and used the method to highlight the importance of MCS between the endoplasmic reticulum (ER) and lipid droplets in metabolic adaptation and MCS between the ER and mitochondria in Ca signal propagation.

摘要

膜接触位点（MCS）是在所有真核细胞中发现的特殊区域，它们在紧密相邻的不同细胞器的膜之间形成。MCS具有重要功能，因为它们是相邻细胞器之间分子高效转移的位点。最近的两篇文章使用了splitFAST系统来标记和追踪膜接触位点的动态，并利用该方法强调了内质网（ER）与脂滴之间的MCS在代谢适应中的重要性，以及ER与线粒体之间的MCS在钙信号传播中的重要性。