Li Mingxiao, Xiao Yili, Dai Ling, Chen Simin, Pei Wanjuan, Tan Chao
Medical School, Hunan University of Chinese Medicine, Changsha, China.
Department of Cardiology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China.
Front Endocrinol (Lausanne). 2025 Jun 5;16:1573499. doi: 10.3389/fendo.2025.1573499. eCollection 2025.
Atherosclerosis (AS) is a global public health concern and involves a complex pathogenesis characterized by lipid abnormalities, oxidative stress, and inflammatory responses at the cellular and molecular levels. The crosstalk between the endoplasmic reticulum (ER) and mitochondria, mediated by mitochondria-associated membranes (MAMs), plays a critical role in the pathogenesis of atherosclerosis. As two key cellular organelles, the ER and mitochondria interact physically and functionally through MAMs, which serve as bridges between their close contact and interdependence. MAMs maintain lipid homeostasis, promote calcium ion transport, the oxidative stress response, apoptosis, and autophagy. Recent studies have highlighted the significance of ER-mitochondria crosstalk in the progression of AS, as indicated by mitochondrial and ER structural and functional integrity, redox homeostasis, and calcium homeostasis. This review comprehensively explores the novel mechanisms of ER-mitochondria crosstalk in AS and emphasizes the potential of MAMs as therapeutic targets, aiming to provide new perspectives and strategies for the treatment of cardiovascular diseases.
动脉粥样硬化（AS）是一个全球性的公共卫生问题，其发病机制复杂，在细胞和分子水平上具有脂质异常、氧化应激和炎症反应等特征。由线粒体相关膜（MAM）介导的内质网（ER）与线粒体之间的相互作用在动脉粥样硬化的发病机制中起关键作用。作为两个关键的细胞器，内质网和线粒体通过线粒体相关膜在物理和功能上相互作用，线粒体相关膜充当它们紧密接触和相互依存之间的桥梁。线粒体相关膜维持脂质稳态，促进钙离子运输、氧化应激反应、细胞凋亡和自噬。最近的研究强调了内质网-线粒体相互作用在动脉粥样硬化进展中的重要性，线粒体和内质网的结构和功能完整性、氧化还原稳态和钙稳态都表明了这一点。这篇综述全面探讨了内质网-线粒体相互作用在动脉粥样硬化中的新机制，并强调了线粒体相关膜作为治疗靶点的潜力，旨在为心血管疾病的治疗提供新的视角和策略。
