Clemens Morgan S, Tyree Maria F, Stenhouse Claire
Department of Animal Science, Pennsylvania State University, University Park, PA, 16802, USA.
Department of Animal Science, Pennsylvania State University, University Park, PA, 16802, USA.
Domest Anim Endocrinol. 2025 Apr;91:106917. doi: 10.1016/j.domaniend.2025.106917. Epub 2025 Jan 16.
Intrauterine growth restriction (IUGR) is a common condition in swine associated with high piglet mortality and morbidity that develops in early gestation. This review article explores differences in uterine and placental tissues associated with IUGR fetuses compared to their normally-grown littermates at different stages of gestation. Specifically, we will review the available knowledge to date describing differences in 1) structure, 2) cellular apoptosis and proliferation, 3) adhesion, and 4) angiogenesis in endometrial and placental tissues associated with IUGR fetuses across gestation. Improved understanding of the mechanisms regulating IUGR is essential for the development of strategies to minimize the impact of IUGR in swine operations, thus improving reproductive efficiency and animal welfare.
宫内生长受限(IUGR)是猪常见的一种情况,与妊娠早期发生的仔猪高死亡率和高发病率相关。这篇综述文章探讨了与宫内生长受限胎儿相关的子宫和胎盘组织,与处于不同妊娠阶段的正常生长同窝仔猪相比的差异。具体而言,我们将回顾迄今为止现有的知识,描述在整个妊娠期与宫内生长受限胎儿相关的子宫内膜和胎盘组织在以下方面的差异:1)结构,2)细胞凋亡和增殖,3)黏附,4)血管生成。更好地理解调节宫内生长受限的机制对于制定策略以尽量减少宫内生长受限对养猪生产的影响至关重要,从而提高繁殖效率和动物福利。