Pei Ziwei, Zhang Lei, Bao Yan, Li Jingguang, Zhuo Qin
NHC Key Laboratory of Public Nutrition and Health, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
China National Center for Food Safety Risk Assessment, Chinese Academy of Medical Sciences Research Unit (No. 2019RU014), Beijing 100021, China.
Ecotoxicol Environ Saf. 2025 Jan 15;290:117790. doi: 10.1016/j.ecoenv.2025.117790. Epub 2025 Jan 24.
In 2023, European Food Safety Authority (EFSA) published a re-evaluation of the safety of bisphenol A (BPA), establishing the new tolerable daily intake (TDI) as 0.2 ng/kg·bw/day with a 20,000-fold reduction compared to 2015, which regained public concern about the impact of bisphenols (BPs) on human health. In order to explore the health risk to thyroid function of BPs, in this study, we assessed the internal exposure levels of BPs and the relationships between urinary BPs and thyroid function in general adults. We carried out a cross-sectional study in Chengdu, China, recruiting 1486 adults without special indentities and diseases (aged 18-68), and measured 6 BPs in urine. We found BPA was the predominant compound in urinary samples of this population, and the estimated daily intake (EDI) of BPA was 0.027 μg/kg·bw/day (geometric mean), exceeding the TDI value by two orders of magnitude. Using multivariable regression model, we observed a negative association between BPA and T3 and T3/T4 in males. Trend tests indicated that higher BPA levels were correlated with higher rates of subclinical hypothyroidism (SCH) in males (OR=1.383, 95 % CI [1.024, 1.867]). We also observed that bisphenol F (BPF) contributed to the occurrence of thyroid globulin antibody positivity (TGAb.P) in both males and females. Although the use of BPs has been restricted, the adverse health effects still deserve public attention.
2023年，欧洲食品安全局（EFSA）发布了对双酚A（BPA）安全性的重新评估，确定新的每日可耐受摄入量（TDI）为0.2纳克/千克体重/天，与2015年相比降低了20000倍，这再次引发了公众对双酚类物质（BPs）对人类健康影响的关注。为了探究双酚类物质对甲状腺功能的健康风险，在本研究中，我们评估了普通成年人中双酚类物质的体内暴露水平以及尿中双酚类物质与甲状腺功能之间的关系。我们在中国成都开展了一项横断面研究，招募了1486名无特殊身份和疾病的成年人（年龄在18 - 68岁），并检测了尿中的6种双酚类物质。我们发现双酚A是该人群尿样中的主要化合物，双酚A的估计每日摄入量（EDI）为0.027微克/千克体重/天（几何均值），超过TDI值两个数量级。使用多变量回归模型，我们观察到男性中双酚A与T3和T3/T4呈负相关。趋势检验表明，男性中双酚A水平越高，亚临床甲状腺功能减退（SCH）的发生率越高（OR = 1.383，95%CI [1.024, 1.867]）。我们还观察到双酚F（BPF）在男性和女性中均促使甲状腺球蛋白抗体阳性（TGAb.P）的发生。尽管双酚类物质的使用已受到限制，但其对健康的不良影响仍值得公众关注。
