Zhu Miaomiao, Cai Qing
Key Laboratory of Brain Functional Genomics (MOE & STCSM), Affiliated Mental Health Center (ECNU), Institute of Brain and Education Innovation, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China; Shanghai Changning Mental Health Center, Shanghai 200335, China; Shanghai Center for Brain Science and Brain-Inspired Technology, East China Normal University, China.
Key Laboratory of Brain Functional Genomics (MOE & STCSM), Affiliated Mental Health Center (ECNU), Institute of Brain and Education Innovation, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China; Shanghai Changning Mental Health Center, Shanghai 200335, China; Shanghai Center for Brain Science and Brain-Inspired Technology, East China Normal University, China; NYU-ECNU Institute of Brain and Cognitive Science, New York University, Shanghai, China.
Brain Lang. 2025 Mar;262:105537. doi: 10.1016/j.bandl.2025.105537. Epub 2025 Jan 24.
Hemispheric specialization of different functions is proposed to confer evolutionary benefits, yet the behavioral impacts of lateralization and its cognitive and neural mechanisms remain unclear. This study investigated the effect of lateralization pattern between language and spatial attention on dual-task performance and its association with callosal connectivity. Functional lateralization was assessed using fMRI verbal fluency and landmark tasks, and interhemispheric connections were evaluated through diffusion-weighted imaging. The typical lateralization pattern enhanced overall performance and reduced interference in dual-task compared to the co-lateralized pattern (both functions lateralized to one hemisphere). However, no differences were observed between the mirrored pattern (right language dominance and left attention dominance) and the co-lateralized pattern. While callosal connectivity did not significantly differ among groups, a negative correlation was observed between the lateralization degree and callosal connectivity. Our findings partially support the functional crowding hypothesis and offer insights into neurocognitive mechanisms underlying functional reorganization after brain lesions.
不同功能的半球特化被认为具有进化优势，然而，大脑半球侧化的行为影响及其认知和神经机制仍不清楚。本研究调查了语言和空间注意力之间的侧化模式对双任务表现的影响及其与胼胝体连接性的关联。使用功能磁共振成像言语流畅性和地标任务评估功能侧化，并通过扩散加权成像评估半球间连接。与同侧化模式（两种功能都偏向一个半球）相比，典型的侧化模式提高了整体表现并减少了双任务中的干扰。然而，镜像模式（右侧语言优势和左侧注意力优势）和同侧化模式之间没有观察到差异。虽然各组之间胼胝体连接性没有显著差异，但观察到侧化程度与胼胝体连接性之间存在负相关。我们的研究结果部分支持功能拥挤假说，并为脑损伤后功能重组的神经认知机制提供了见解。
