Zago Laure, Petit Laurent, Jobard Gael, Hay Julien, Mazoyer Bernard, Tzourio-Mazoyer Nathalie, Karnath Hans-Otto, Mellet Emmanuel
Université de Bordeaux, Institut des Maladies Neurodégénératives, Groupe d'Imagerie Neurofonctionnelle, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, Groupe d'Imagerie Neurofonctionnelle, UMR 5293, F-33000 Bordeaux, France; CEA, Institut des Maladies Neurodégénératives, Groupe d'Imagerie Neurofonctionnelle, UMR 5293, F-33000 Bordeaux, France.
Université de Bordeaux, Institut des Maladies Neurodégénératives, Groupe d'Imagerie Neurofonctionnelle, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, Groupe d'Imagerie Neurofonctionnelle, UMR 5293, F-33000 Bordeaux, France; CEA, Institut des Maladies Neurodégénératives, Groupe d'Imagerie Neurofonctionnelle, UMR 5293, F-33000 Bordeaux, France.
Neuropsychologia. 2017 Jan 8;94:75-83. doi: 10.1016/j.neuropsychologia.2016.11.024. Epub 2016 Dec 1.
The objective of this study was to validate a line bisection judgement (LBJ) task for use in investigating the lateralized cerebral bases of spatial attention in a sample of 51 right-handed healthy participants. Using functional magnetic resonance imaging (fMRI), the participants performed a LBJ task that was compared to a visuomotor control task during which the participants made similar saccadic and motoric responses. Cerebral lateralization was determined using a voxel-based functional asymmetry analysis and a hemispheric functional lateralization index (HFLI) computed from fMRI contrast images. Behavioural attentional deviation biases were assessed during the LBJ task and a "paper and pencil" symbol cancellation task (SCT). Individual visuospatial skills were also evaluated. The results showed that both the LBJ and SCT tasks elicited leftward spatial biases in healthy subjects, although the biases were not correlated, which indicated their independence. Neuroimaging results showed that the LBJ task elicited a right hemispheric lateralization, with rightward asymmetries found in a large posterior occipito-parietal area, the posterior calcarine sulcus (V1p) and the temporo-occipital junction (TOJ) and in the inferior frontal gyrus, the anterior insula and the superior medial frontal gyrus. The comparison of the LBJ asymmetry map to the lesion map of neglect patients who suffer line bisection deviation demonstrated maximum overlap in a network that included the middle occipital gyrus (MOG), the TOJ, the anterior insula and the inferior frontal region, likely subtending spatial LBJ bias. Finally, the LBJ task-related cerebral lateralization was specifically correlated with the LBJ spatial bias but not with the SCT bias or with the visuospatial skills of the participants. Taken together, these results demonstrated that the LBJ task is adequate for investigating spatial lateralization in healthy subjects and is suitable for determining the factors underlying the variability of spatial cerebral lateralization.
本研究的目的是验证一种直线二等分判断（LBJ）任务，用于在51名右利手健康参与者的样本中研究空间注意的大脑侧化基础。使用功能磁共振成像（fMRI），参与者执行了一项LBJ任务，并将其与视觉运动控制任务进行比较，在视觉运动控制任务中，参与者做出了类似的眼球跳动和运动反应。使用基于体素的功能不对称分析和从fMRI对比图像计算得出的半球功能侧化指数（HFLI）来确定大脑侧化。在LBJ任务和“纸笔”符号消除任务（SCT）期间评估行为注意偏差。还评估了个体的视觉空间技能。结果表明，LBJ和SCT任务在健康受试者中均引发了向左的空间偏差，尽管这些偏差不相关，这表明它们是独立的。神经影像学结果表明，LBJ任务引发了右半球侧化，在大的枕顶后区、后距状沟（V1p）和颞枕交界区（TOJ）以及额下回、前岛叶和额上内侧回中发现了向右的不对称。将LBJ不对称图谱与患有直线二等分偏差的忽视患者的病变图谱进行比较，发现在一个包括枕中回（MOG）、TOJ、前岛叶和额下区域的网络中重叠最大，可能是空间LBJ偏差的基础。最后，与LBJ任务相关的大脑侧化与LBJ空间偏差具有特异性相关性，但与SCT偏差或参与者的视觉空间技能无关。综上所述，这些结果表明，LBJ任务适用于研究健康受试者的空间侧化，并且适合于确定大脑空间侧化变异性的潜在因素。
