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从正弦灌注模型和静脉平衡模型估算的非线性药代动力学参数的比较。

Comparison of nonlinear pharmacokinetic parameters estimated from the sinusoidal perfusion and venous equilibrium models.

作者信息

Wagner J G

出版信息

Biopharm Drug Dispos. 1985 Jan-Mar;6(1):23-31. doi: 10.1002/bdd.2510060104.

DOI:10.1002/bdd.2510060104
PMID:3986299
Abstract

It is shown that the intrinsic and steady-state clearances and the values of Vm and Km of the Michaelis-Menten equation estimated via the sinusoidal perfusion model are different from the corresponding values estimated via the venous equilibration model. The liver blood flow rates estimated by two theories (from plasma data) are identical. The comparison was made using the single dose oral and intravenous and steady-state oral plasma concentration-time data for verapamil in six subjects previously published.

摘要

结果表明，通过正弦灌注模型估算的米氏方程的内在清除率、稳态清除率以及Vm和Km值，与通过静脉平衡模型估算的相应值不同。两种理论（根据血浆数据）估算的肝血流量相同。利用先前发表的6名受试者维拉帕米的单剂量口服、静脉注射及稳态口服血浆浓度-时间数据进行了比较。

相似文献

1
Comparison of nonlinear pharmacokinetic parameters estimated from the sinusoidal perfusion and venous equilibrium models.从正弦灌注模型和静脉平衡模型估算的非线性药代动力学参数的比较。
Biopharm Drug Dispos. 1985 Jan-Mar;6(1):23-31. doi: 10.1002/bdd.2510060104.
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引用本文的文献

1
A nonlinear physiologic pharmacokinetic model: I. Steady-state.一种非线性生理药代动力学模型：I. 稳态
J Pharmacokinet Biopharm. 1985 Feb;13(1):73-92. doi: 10.1007/BF01073657.
2
Prediction of hepatic first-pass metabolism and plasma levels following intravenous and oral administration of barbiturates in the rabbit based on quantitative structure-pharmacokinetic relationships.基于定量构效关系预测巴比妥类药物静脉注射和口服给药后家兔的肝首过代谢及血浆水平。
J Pharmacokinet Biopharm. 1988 Jun;16(3):279-301. doi: 10.1007/BF01062138.
3
Clinical significance of pharmacokinetic models of hepatic elimination.
肝脏消除药代动力学模型的临床意义。
Clin Pharmacokinet. 1990 Jan;18(1):61-76. doi: 10.2165/00003088-199018010-00004.