静脉平衡（“充分搅拌”）模型、窦状灌注（“平行管”）模型与特定双室开放模型的精确数学等效性。 - Suppr

Suppr

超能文献

Exact mathematical equivalence of the venous equilibration ("well-stirred") model, the sinusoidal perfusion ("parallel-tube") model, and a specific two-compartment open model.

作者信息

Wagner J G, Szpunar G J, Ferry J J

出版信息

Drug Metab Dispos. 1984 Jul-Aug;12(4):385-8.

PMID:6148202

Abstract

摘要

相似文献

Exact mathematical equivalence of the venous equilibration ("well-stirred") model, the sinusoidal perfusion ("parallel-tube") model, and a specific two-compartment open model.静脉平衡（“充分搅拌”）模型、窦状灌注（“平行管”）模型与特定双室开放模型的精确数学等效性。

Drug Metab Dispos. 1984 Jul-Aug;12(4):385-8.

Relationships among the venous equilibration ("well-stirred") model, the sinusoidal perfusion ("parallel-tube") model, and a specific two-compartment open model.静脉平衡（“充分混合”）模型、肝血窦灌注（“平行管”）模型与特定二室开放模型之间的关系。

Drug Metab Dispos. 1985 Mar-Apr;13(2):119-20.

The series-compartment model for hepatic elimination.

Drug Metab Dispos. 1987 Jan-Feb;15(1):27-31.

In vitro kinetics of drug release from oral dosage forms, lyophilized and conventional rectal suppositories. I. Mathematical considerations applicable to a two compartment open model system simulating more realistic in vivo conditions.口服剂型、冻干直肠栓剂和传统直肠栓剂的体外药物释放动力学。I. 适用于模拟更真实体内条件的双室开放模型系统的数学考量。

Pharm Acta Helv. 1975;50(9):279-82.

[Mathematical analysis concerning the dosage regimen of intravenous infusion of two-compartment model drugs (author's transl)].二室模型药物静脉滴注给药方案的数学分析（作者译）

Yao Xue Xue Bao. 1980 Dec;15(12):741-9.

Comparison of nonlinear pharmacokinetic parameters estimated from the sinusoidal perfusion and venous equilibrium models.从正弦灌注模型和静脉平衡模型估算的非线性药代动力学参数的比较。

Biopharm Drug Dispos. 1985 Jan-Mar;6(1):23-31. doi: 10.1002/bdd.2510060104.

Misuse of the well-stirred model of hepatic drug clearance.肝脏药物清除率充分搅拌模型的误用。

Drug Metab Dispos. 2007 Mar;35(3):501-2. doi: 10.1124/dmd.106.013359.

Application of the modified one-compartment open model in pharmacokinetic investigations.改良的单室开放模型在药代动力学研究中的应用。

Pharmazie. 1985 Feb;40(2):120-1.

[Sampling design of linear one compartment open model for drug administered via non-blood-vessel way (author's transl)].

Yao Xue Xue Bao. 1981 Oct;16(10):732-40.

[Calculation of rate constants for linear three-compartment open models].[线性三室开放模型速率常数的计算]

Zhongguo Yao Li Xue Bao. 1983 Jun;4(2):77-81.

引用本文的文献

A nonlinear physiologic pharmacokinetic model: I. Steady-state.一种非线性生理药代动力学模型：I. 稳态

J Pharmacokinet Biopharm. 1985 Feb;13(1):73-92. doi: 10.1007/BF01073657.

Theophylline. Pooled Michaelis-Menten parameters (Vmax and Km) and implications.茶碱。米氏参数汇总（最大反应速度Vmax和米氏常数Km）及其意义。

Clin Pharmacokinet. 1985 Sep-Oct;10(5):432-42. doi: 10.2165/00003088-198510050-00005.

The influence of binding to albumin and alpha 1-acid glycoprotein on the clearance of drugs by the liver.与白蛋白和α1-酸性糖蛋白结合对肝脏药物清除率的影响。

Pharm Weekbl Sci. 1987 Apr 24;9(2):65-74. doi: 10.1007/BF01960738.

Prediction of hepatic first-pass metabolism and plasma levels following intravenous and oral administration of barbiturates in the rabbit based on quantitative structure-pharmacokinetic relationships.基于定量构效关系预测巴比妥类药物静脉注射和口服给药后家兔的肝首过代谢及血浆水平。

J Pharmacokinet Biopharm. 1988 Jun;16(3):279-301. doi: 10.1007/BF01062138.

Clinical significance of pharmacokinetic models of hepatic elimination.肝脏消除药代动力学模型的临床意义。

Clin Pharmacokinet. 1990 Jan;18(1):61-76. doi: 10.2165/00003088-199018010-00004.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验