Williams C M, Ellis R
Biosci Rep. 1985 Feb;5(2):175-84. doi: 10.1007/BF01117064.
Male rats were treated with triiodothyronine in the drinking water for 12 days. In vitro rates of isoprenaline stimulated lipolysis were significantly greater in brown but not white adipose tissue. Rates of [14C]glucose incorporation into triacylglycerols were significantly reduced in BAT (brown adipose tissue) and WAT (white adipose tissue) under basal and isoprenaline stimulated conditions. In a second experiment, hyperthyroid animals showed impaired weight gain, despite increased food intake during 19 days' treatment. Energy expenditure on days 5 and 12, and BAT core temperature differences (TBAT - TCORE) on day 19, were significantly greater than in control animals. Epididymal white fat pad weight was reduced and interscapular brown fat pad weight increased by triiodothyronine treatment.
雄性大鼠在饮用水中添加三碘甲状腺原氨酸处理12天。在体外，异丙肾上腺素刺激的脂肪分解速率在棕色脂肪组织中显著更高，但在白色脂肪组织中并非如此。在基础和异丙肾上腺素刺激条件下，棕色脂肪组织（BAT）和白色脂肪组织（WAT）中[14C]葡萄糖掺入三酰甘油的速率显著降低。在第二个实验中，甲状腺功能亢进的动物尽管在19天的治疗期间食物摄入量增加，但体重增加受损。第5天和第12天的能量消耗以及第19天的棕色脂肪组织核心温度差异（TBAT - TCORE）显著高于对照动物。三碘甲状腺原氨酸处理使附睾白色脂肪垫重量减轻，肩胛间棕色脂肪垫重量增加。
