Zharkovskiĭ A M, Zharkovskaia T A, Chereshka K S
Biull Eksp Biol Med. 1985 Mar;99(3):314-5.
In experiments on mice 3H-spiperone binding after intraperitoneal injection was studied. The binding of 3H-spiperone was saturable in the frontal cortex and subcortical structures, whereas in the cerebellum, the amount of radioactivity increased in a linear manner and was referred to as nonspecific binding. The neuroleptics haloperidol, chlorpromazine and sulpiride given 0.5 h before 3H-spiperone displaced 3H-spiperone in the subcortical structures in a dose-related manner. Although the level of the specific 3H-spiperone binding after intraperitoneal injection was lower than after intravenous injection, the intraperitoneal method is simpler, well reproduced and given results comparable with the intravenous method.
在小鼠实验中，研究了腹腔注射后3H-螺哌隆的结合情况。3H-螺哌隆在额叶皮质和皮质下结构中的结合具有饱和性，而在小脑中，放射性活度呈线性增加，被称为非特异性结合。在注射3H-螺哌隆前0.5小时给予的抗精神病药物氟哌啶醇、氯丙嗪和舒必利，以剂量相关的方式取代了皮质下结构中的3H-螺哌隆。虽然腹腔注射后3H-螺哌隆特异性结合水平低于静脉注射后，但腹腔注射方法更简单，重复性好，所得结果与静脉注射方法相当。
