[Effect of compensatory hypertrophy of the kidney on the ability of splenocytes to induce a regional graft versus host reaction].

The ability of C57BL/6 mouse splenocytes to induce regional GVHR during uni- and bilateral nephrectomy, ligation of the ureter and sham operations was studied. It was shown that any kidney operation enhances the ability of splenocytes to induce the GVHR in contrast to uni- and bilateral sham operations. This phenomenon was first observed during bilateral nephrectomy (after 5 h), unilateral nephrectomy (after 24 h) and ligation of the ureter (after 72 h). The data indicate that deficiency of the tissue is the main cause of changes in the immunity system status rather than changes in antigen properties and functional insufficiency of the kidneys.