Babaeva A G, Gimmel'farb E I
Biull Eksp Biol Med. 1985 Mar;99(3):336-8.
The ability of C57BL/6 mouse splenocytes to induce regional GVHR during uni- and bilateral nephrectomy, ligation of the ureter and sham operations was studied. It was shown that any kidney operation enhances the ability of splenocytes to induce the GVHR in contrast to uni- and bilateral sham operations. This phenomenon was first observed during bilateral nephrectomy (after 5 h), unilateral nephrectomy (after 24 h) and ligation of the ureter (after 72 h). The data indicate that deficiency of the tissue is the main cause of changes in the immunity system status rather than changes in antigen properties and functional insufficiency of the kidneys.
研究了C57BL/6小鼠脾细胞在单侧和双侧肾切除术、输尿管结扎术及假手术过程中诱导局部移植物抗宿主反应（GVHR）的能力。结果表明，与单侧和双侧假手术相比，任何肾脏手术都会增强脾细胞诱导GVHR的能力。这种现象首先在双侧肾切除术（5小时后）、单侧肾切除术（24小时后）和输尿管结扎术（72小时后）中观察到。数据表明，组织缺损是免疫系统状态变化的主要原因，而非抗原特性的改变和肾脏的功能不全。
