[Antibody formation in experimental kidney failure and in the early stages of restorative kidney growth in mice].

The ability of spleen cells to respond with antibody formation to a foreign antigen (sheep erythrocytes) was studied in mice at different kidney lesions (uni- and bilateral nephrectomy, ureter ligation, pseudo-operation, wound of one kidney) during the early postoperation period (1-72 h). In the case of bilateral nephrectomy, the reliable increase in the number of antibody-forming cells (AFC) was noted already within 1 h after the operation, in the case of unilateral nephrectomy within 12 h. In the case of bi- and unilateral ligations of ureter, the response was delayed by 3 and 5 h, respectively. Sham operation and kidney wound did not stimulate antibody formation. It is suggested that the antibody-forming ability of the spleen cells does not depend on stress, renal deficiency or destructive changes and that the antibody formation is activated by disturbances in the ratio of immunoregulatory cells.