Babaeva A G, Gimmel'farb E I
Ontogenez. 1988 Jan-Feb;19(1):42-7.
The ability of spleen cells to respond with antibody formation to a foreign antigen (sheep erythrocytes) was studied in mice at different kidney lesions (uni- and bilateral nephrectomy, ureter ligation, pseudo-operation, wound of one kidney) during the early postoperation period (1-72 h). In the case of bilateral nephrectomy, the reliable increase in the number of antibody-forming cells (AFC) was noted already within 1 h after the operation, in the case of unilateral nephrectomy within 12 h. In the case of bi- and unilateral ligations of ureter, the response was delayed by 3 and 5 h, respectively. Sham operation and kidney wound did not stimulate antibody formation. It is suggested that the antibody-forming ability of the spleen cells does not depend on stress, renal deficiency or destructive changes and that the antibody formation is activated by disturbances in the ratio of immunoregulatory cells.
在术后早期（1 - 72小时），研究了处于不同肾脏病变（单侧和双侧肾切除术、输尿管结扎、假手术、一侧肾脏创伤）的小鼠脾脏细胞针对外来抗原（绵羊红细胞）产生抗体形成的能力。在双侧肾切除的情况下，术后1小时内即可观察到抗体形成细胞（AFC）数量可靠增加；单侧肾切除则在12小时内出现这种情况。在双侧和单侧输尿管结扎的情况下，反应分别延迟3小时和5小时。假手术和肾脏创伤并未刺激抗体形成。研究表明，脾脏细胞的抗体形成能力并不依赖于应激、肾亏或破坏性变化，且抗体形成是由免疫调节细胞比例的紊乱所激活的。
