Wright Mallory, Kaur Mandeep, Thompson Laura K, Cox Georgina
College of Biological Sciences, Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Rd E, Guelph, ON, Canada.
NPJ Antimicrob Resist. 2025 Jan 25;3(1):6. doi: 10.1038/s44259-025-00078-3.
Since its discovery nearly 60 years ago, TolC has been associated with various cellular functions in Escherichia coli, including the efflux of environmental stressors and virulence factors. It also acts as a receptor for specific bacteriophages and the colicin E1 toxin. This review highlights key discoveries over the past six decades and emphasizes the remaining gaps in understanding how TolC contributes to physiological functions in E. coli.
自近60年前被发现以来，TolC一直与大肠杆菌的各种细胞功能相关联，包括环境应激源和毒力因子的外排。它还作为特定噬菌体和大肠杆菌素E1毒素的受体。这篇综述重点介绍了过去六十年来的关键发现，并强调了在理解TolC如何促进大肠杆菌生理功能方面仍存在的差距。
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