Jiang Lina, Ma Zhenghao, Song Luwen, Zhu Chenchen, Li Jiancheng, Su Zhenxing, Liu Hongsheng
School of Stomatology, Bengbu Medical University, No. 2600 Donghai Road, Bengbu, 233030, China.
The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Sci Rep. 2025 Jan 25;15(1):3195. doi: 10.1038/s41598-025-87637-w.
Tongue squamous cell carcinoma (TSCC) is a common malignant oral cancer characterized by substantial invasion, a high rate of lymph node and distant metastasis, and a high recurrence rate. This study aims to provide new ideas for the diagnosis and treatment of TSCC patients by exploring the related mechanisms that affect the migration and invasion of TSCC and inhibit the migration and spread of cancer cells. The results indicated the rate of high expression of IL-17 in cancer tissues was greater than that in tongue tissues, and the expression of IL-17 was related to the TNM stage. The expression of IL-17 in Cal-27 cells was greater than that in HOEC. With increasing IL-17 concentration, cell proliferation, migration, and invasion increased, and the apoptosis rate decreased. After adding the IL-17 inhibitor, the cell proliferation, invasion, and migration abilities decreased, the apoptosis rate increased, and the expression of JAK1and p-STAT3 decreased.IL-17 is highly expressed in oral tongue squamous cell carcinoma and is involved in the occurrence and development of TSCC, possibly through the JAK‒Stat signaling pathway. This study provides a new target and theoretical basis for treating tongue squamous cell carcinoma.
舌鳞状细胞癌（TSCC）是一种常见的口腔恶性肿瘤，其特征为侵袭性强、淋巴结转移和远处转移率高以及复发率高。本研究旨在通过探索影响TSCC迁移和侵袭并抑制癌细胞迁移和扩散的相关机制，为TSCC患者的诊断和治疗提供新思路。结果表明，癌组织中IL-17的高表达率高于舌组织，且IL-17的表达与TNM分期有关。Cal-27细胞中IL-17的表达高于人正常口腔角质形成细胞（HOEC）。随着IL-17浓度的增加，细胞增殖、迁移和侵袭增加，凋亡率降低。添加IL-17抑制剂后，细胞增殖、侵袭和迁移能力降低，凋亡率增加，JAK1和p-STAT3的表达降低。IL-17在口腔舌鳞状细胞癌中高表达，并可能通过JAK-Stat信号通路参与TSCC的发生和发展。本研究为治疗舌鳞状细胞癌提供了新的靶点和理论依据。
