Exposure to smoking and greenspace are associated with allergy medicine use - A study of wastewaterin 28 cities of China.

Allergies have become an important public health issue as their occurrence is reportedly on the rise around the world. Exposure to environmental factors is considered as trigger for allergic diseases. However, there was limited data on the importance of each factor, particularly in China. In this study, we aimed to investigate the association between occurrence of allergic diseases with exposure to multiple environmental factors via wastewater surveillance across 28 cities in China. The surveillance was conducted by measuring biomarkers of proxies of allergic diseases, i.e. antihistamines, asthma drug, and of smoking, i.e. cotinine in wastewater. Data of green space and air quality were also collected. We observed the level of antihistamine use were significantly associated with smoking, green space and pollen but not significant with air pollution. People in Northern China used more antihistamines than their compatriots in Southern China, an observation aligning with previous reporting of more allergy prevalence in the North than the South of China. Our study affirmed that in China smoking is responsible for a rise in allergy and asthma in the population. Meanwhile, selected sensitizing pollens (occurring during summer) could have stronger impact to trigger allergies than other pollens (occurring in winter).