Tsuang M T, Faraone S V, Fleming J A
Br J Psychiatry. 1985 Mar;146:268-71. doi: 10.1192/bjp.146.3.268.
The two-threshold multifactorial polygenic (MFP) model was applied to blind family study data, collected in a long-term follow-up and family study of major affective disorders. This model tested whether bipolar and unipolar disorders are manifestations of the same underlying factors or if they are independently caused disorders. The hypothesis that bipolar and unipolar disorders are, respectively, severe and mild forms of the same disorder was supported. There was little evidence for different familial aetiologies for bipolar and unipolar disorders in our sample.
双阈值多因素多基因（MFP）模型应用于在一项针对重性情感障碍的长期随访和家族研究中收集的盲法家族研究数据。该模型检验了双相情感障碍和单相情感障碍是同一潜在因素的表现形式，还是由独立病因导致的疾病。双相情感障碍和单相情感障碍分别是同一疾病的重度和轻度形式这一假设得到了支持。在我们的样本中，几乎没有证据表明双相情感障碍和单相情感障碍存在不同的家族病因。
