Markowska A, Bakke H K, Walther B, Ursin H
Brain Res. 1985 Mar 4;328(2):313-23. doi: 10.1016/0006-8993(85)91043-1.
Electrolytic lesions in the lateral hypothalamus (LH) seriously affect ingestive behavior and sensorimotor functions in the rat. We here report that bilateral infusions of the neurotoxin, ibotenic acid (IBO) in the LH yield a decrease in body weight, but not to the same extent as electrolytic lesions. The sensorimotor impairments were most severe after electrolytic lesions. When tested in a residential maze on days 5-7 and 18-20 after surgery, both lesioned groups showed no lack of motivation to seek food and water. Histological examination of the LH following IBO exposure revealed extensive degeneration of neuronal cell bodies with little evidence of non-specific damage. Biochemical analysis of the rostral forebrain content of norepinephrine (NE) and serotonin (5-HT) revealed that the fibers passing through the LH remained largely intact in the IBO treated rats. The results suggest that the observed aphagia and adipsia is not due to a lack of motivation, but rather reflects changes in the process which operate to initiate eating and drinking. Furthermore, selective neuronal degeneration induced the same behavioral changes as the electrolytic ones, though not to the same extent.
下丘脑外侧区（LH）的电解损伤会严重影响大鼠的摄食行为和感觉运动功能。我们在此报告，向LH双侧注入神经毒素鹅膏蕈氨酸（IBO）会导致体重下降，但程度不如电解损伤。电解损伤后感觉运动障碍最为严重。在手术后第5 - 7天和第18 - 20天在居住迷宫中进行测试时，两个损伤组都没有表现出缺乏寻找食物和水的动机。对接受IBO处理后的LH进行组织学检查发现，神经元细胞体广泛退化，几乎没有非特异性损伤的迹象。对前脑前部去甲肾上腺素（NE）和5 - 羟色胺（5 - HT）含量的生化分析表明，在接受IBO处理的大鼠中，穿过LH的纤维基本保持完整。结果表明，观察到的摄食和饮水缺乏并非由于动机不足，而是反映了启动进食和饮水过程中的变化。此外，选择性神经元退化诱导了与电解损伤相同的行为变化，尽管程度不同。
