Winn P, Tarbuck A, Dunnett S B
Neuroscience. 1984 May;12(1):225-40. doi: 10.1016/0306-4522(84)90149-0.
Rats received either ibotenic acid, electrolytic or sham lesions of the lateral hypothalamic area. Compared to sham operated rats, both lesion groups showed aphagia and adipsia following the lesion; this was less severe in the ibotenic acid lesioned rats. Once recovered, the ibotenic acid lesioned rats showed residual regulatory impairments in their compensatory responses to glucoprivation and to extracellular and intracellular dehydration. However, unlike the electrolytic lesioned rats, those with ibotenic acid lesions did not show akinesia and exhibited normal responses to both d-amphetamine and apomorphine. Ibotenic acid lesions resulted in extensive loss of cell bodies within the lateral hypothalamic area while sparing ascending dopamine neurones. The results are interpreted as suggesting that the lateral hypothalamic area and ascending dopamine neurones are components of a single system involved in the regulation of food and water intake.
给大鼠的下丘脑外侧区注射鹅膏蕈氨酸、进行电解损伤或假损伤。与假手术的大鼠相比，两个损伤组在损伤后均出现摄食和饮水减少的情况；鹅膏蕈氨酸损伤的大鼠这种情况较轻。恢复后，鹅膏蕈氨酸损伤的大鼠在对糖剥夺以及细胞外和细胞内脱水的代偿反应中表现出残余的调节障碍。然而，与电解损伤的大鼠不同，鹅膏蕈氨酸损伤的大鼠没有出现运动不能，并且对d-苯丙胺和阿扑吗啡均表现出正常反应。鹅膏蕈氨酸损伤导致下丘脑外侧区内的细胞体大量丧失，同时保留了上行多巴胺神经元。这些结果被解释为表明下丘脑外侧区和上行多巴胺神经元是参与食物和水摄入调节的单一系统的组成部分。
