Torigoe K
Brain Res. 1985 Mar 25;330(2):273-82. doi: 10.1016/0006-8993(85)90686-9.
The distribution and frequency of motor nerve sproutings in the mouse gastrocnemius muscle were examined after a partial denervation. Terminal and nodal sproutings could be seen for a period of 7-28 days after transecting one of the two muscular nerves in the medial head. They grew out not only from the endplates and terminal nerves, but also from the preterminal nerve regions of both the intra- and extramuscular nerve. The terminal sproutings originated from endplates close to the denervated portion and subsequently they were seen farther away in the medial head. Upon regeneration of the originally transected nerve the terminal sproutings were withdrawn in the reverse sequence, i.e., first from the region farthest from the denervated area and last from the region adjacent to the denervation. The frequency of terminal sproutings was constant in the area immediately bordering the denervated portion (11-15% of the total number of endplates). In other areas more distant from the denervated portion, however, it showed a gradient which varied with the time course. The higher the frequency of terminal sproutings, the more actively each endplate produced two or three terminal sproutings without significant difference in length.
在部分去神经支配后，对小鼠腓肠肌运动神经发芽的分布和频率进行了检查。在内侧头肌两条肌肉神经中的一条横断后7至28天内，可以看到终末和结旁发芽。它们不仅从终板和终末神经长出，还从肌内和肌外神经的终末前神经区域长出。终末发芽起源于靠近去神经支配部分的终板，随后在内侧头肌中更远的地方被观察到。当最初横断的神经再生时，终末发芽以相反的顺序撤回，即首先从离去神经支配区域最远的区域撤回，最后从与去神经支配相邻的区域撤回。在紧邻去神经支配部分的区域，终末发芽的频率是恒定的（占终板总数的11 - 15%）。然而，在离去神经支配部分更远的其他区域，它呈现出一个随时间变化的梯度。终末发芽的频率越高，每个终板产生两到三个终末发芽的活性就越高，长度上没有显著差异。
