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植物脂质体——解析植物源纳米技术药物递送系统的独特性质:综述

Phytosomes-unraveling the Unique Properties of Plant-derived Nanotechnological Drug Delivery Systems: A Review.

作者信息

Deniz Fatima Sezer Senol, Demiroz Fatma Nur Tugcu, Ulutas Onur Kenan, Erdogan Ilkay Orhan

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330, Ankara, Türkiye.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, 06330, Ankara, Türkiye.

出版信息

Curr Med Chem. 2025 Jan 24. doi: 10.2174/0109298673319759250116104648.

Abstract

Phytosomes are innovative compounds that enhance the bioavailability of plant-derived compounds, making them more effective in pharmaceuticals and nutraceuticals. By improving cellular absorption, phytosomes allow lower doses of plant extracts to achieve therapeutic effects, which may reduce both cost and the risk of potential side effects. The incorporation of phospholipids in phytosomes not only stabilizes the active compounds but also protects them from degradation in the gastrointestinal tract, potentially increasing their shelf life and efficacy. Despite their promise, more clinical trials are essential to fully validate the safety and therapeutic benefits of phytosomes. Ongoing research and developments may lead to a better understanding of their mechanisms of action and safety profiles and broaden their application in medicine.

摘要

植物脂质体是一种创新型化合物,可提高植物源化合物的生物利用度,使其在制药和营养保健品领域更具效力。通过改善细胞吸收,植物脂质体使较低剂量的植物提取物就能达到治疗效果,这可能会降低成本以及潜在副作用的风险。在植物脂质体中加入磷脂不仅能稳定活性化合物,还能保护它们在胃肠道中不被降解,从而有可能延长其保质期并提高疗效。尽管它们前景广阔,但仍需要更多临床试验来充分验证植物脂质体的安全性和治疗益处。正在进行的研究和开发可能会使人们更好地理解其作用机制和安全性,并拓宽它们在医学中的应用。

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