Santos Igor R, Paz Milena C, Bandinelli Marcele B, Fett Rochana R, Rissi Daniel R, Sousa Renato S, Swist Shannon, Pavarini Saulo P
Department of Veterinary Pathology, College of Veterinary Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Chatterie Centro de Saúde do Gato, Porto Alegre, Rio Grande do Sul, Brazil.
J Vet Diagn Invest. 2025 Mar;37(2):389-392. doi: 10.1177/10406387241312895. Epub 2025 Jan 27.
Feline meningiomas typically arise on the surface of the brain but can occur in the third ventricle. Meningiomas in the fourth ventricle have not been reported in cats, to our knowledge. Here, we describe the clinical and pathologic findings of meningioma in the fourth ventricle in 2 cats. Both affected patients (1 castrated male, 1 spayed female) were 15-y-old. Case 2 had neurologic signs, including absent menace response, head tilt, and ataxia. Grossly, both tumors were well-demarcated and firm, expanded the fourth ventricle, and compressed the adjacent neuroparenchyma. Cytology of the ventricular mass in case 1 revealed a spindle-cell neoplasm. Based on histology, the neoplasms were classified as WHO grade 1 fibrous meningioma (case 1) and transitional meningioma (case 2). Immunohistochemistry revealed diffuse, robust cytoplasmic E-cadherin and vimentin immunolabeling in both cases and multifocal, weak cytoplasmic pan-cytokeratin AE1/AE3 immunolabeling in case 2. Our findings indicate that meningiomas should be included as a differential diagnosis for tumors of the fourth ventricle in cats.
猫脑膜瘤通常起源于脑表面，但也可发生于第三脑室。据我们所知，猫第四脑室的脑膜瘤尚未见报道。在此，我们描述了2只猫第四脑室脑膜瘤的临床和病理表现。两只患病猫（1只去势雄猫，1只绝育雌猫）均为15岁。病例2有神经学症状，包括威胁反应消失、头部倾斜和共济失调。大体上，两个肿瘤均界限清楚、质地硬，使第四脑室扩张，并压迫相邻的神经实质。病例1脑室肿块的细胞学检查显示为梭形细胞瘤。根据组织学，肿瘤被分类为世界卫生组织1级纤维性脑膜瘤（病例1）和过渡性脑膜瘤（病例2）。免疫组化显示，两例均有弥漫性、强阳性的细胞质E-钙黏蛋白和波形蛋白免疫标记，病例2有多灶性、弱阳性的细胞质泛细胞角蛋白AE1/AE3免疫标记。我们的研究结果表明，脑膜瘤应被纳入猫第四脑室肿瘤的鉴别诊断。
