Samuhasaneeto Suchittra, Yusakul Gorawit, Punsawad Chuchard, Bunluepuech Kingkan
School of Medicine, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Research Center in Tropical Pathobiology, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Heliyon. 2025 Jan 3;11(1):e41671. doi: 10.1016/j.heliyon.2025.e41671. eCollection 2025 Jan 15.
Ya That Somdun (YTS) is a traditional Thai medicine composed of six herbs used as a strengthening tonic. Some of the herbs constituting YTS have antihyperlipidemic and anti-obesity activities. The objective of this study was to elucidate the antihyperlipidemic properties of YTS extract in rats with cholesterol suspension-induced hyperlipidemia. Male Sprague-Dawley rats were subdivided into four groups: normal control (NC), hyperlipidemic control (HC), and those who were administered 100 (YTS100) and 200 mg (YTS200) of YTS/kg body weight (BW). Hyperlipidemic rats were orally administered YTS extract for four consecutive weeks from the fifth week of cholesterol suspension. Serum lipid profiles, body weights, liver and renal functional markers, gene expression involved in lipid metabolism, and liver histopathology were examined. The HC and YTS groups showed a significant increase in body weights compared with the NC group. The YTS100 and YTS200 groups showed no significant difference in serum triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels compared with the NC and HC groups. YTS treatment (100 mg/kg BW) downregulated sterol regulatory element binding protein 1c () mRNA expression and alleviated hepatic steatosis. In conclusion, the YTS extract reduced hepatic lipid accumulation in hyperlipidemic rats by reducing SREBP-1c expression levels.
亚他颂丹（YTS）是一种由六种草药组成的泰国传统药物，用作滋补强身剂。构成YTS的一些草药具有降血脂和抗肥胖活性。本研究的目的是阐明YTS提取物对胆固醇混悬液诱导的高脂血症大鼠的降血脂特性。雄性Sprague-Dawley大鼠分为四组：正常对照组（NC）、高脂血症对照组（HC），以及分别给予100（YTS100）和200毫克（YTS200）YTS/千克体重（BW）的组。从胆固醇混悬液处理的第五周开始，对高脂血症大鼠连续四周口服给予YTS提取物。检测血清脂质谱、体重、肝脏和肾脏功能指标、参与脂质代谢的基因表达以及肝脏组织病理学。与NC组相比，HC组和YTS组体重显著增加。与NC组和HC组相比，YTS100组和YTS200组的血清甘油三酯、总胆固醇、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）水平无显著差异。YTS处理（100毫克/千克BW）下调了固醇调节元件结合蛋白1c（）mRNA表达并减轻了肝脂肪变性。总之，YTS提取物通过降低SREBP-1c表达水平减少了高脂血症大鼠肝脏脂质积累。
