From the Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Preventive Cardiology and Lipidology, Medical University of Lodz, Lodz, Poland.
Drugs. 2022 Apr;82(5):559-576. doi: 10.1007/s40265-022-01691-6. Epub 2022 Mar 18.
The treatment of dyslipidemia continues to be a dynamic and controversial topic. Even the most appropriate therapeutic range for lipid levels-including that of triglycerides and low-density lipoprotein cholesterol-remain actively debated. Furthermore, with ever-increasing options and available treatment modalities, the management of dyslipidemia has progressed in both depth and complexity. An understanding of appropriate lipid-lowering therapy remains an essential topic of review for practitioners across medical specialties. The goal of this review is to provide an overview of recent research developments and recommendations for patients with dyslipidemia as a means of better informing the clinical practice of lipid management. By utilizing a guideline-directed approach, we provide a reference point on optimal lipid-lowering therapies across the spectrum of dyslipidemia. Special attention is paid to long-term adherence to lipid-lowering therapies, and the benefits derived from instituting appropriate medications in a structured manner alongside monitoring. Novel therapies and their impact on lipid lowering are discussed in detail, as well as potential avenues for research going forward. The prevention of cardiovascular disease remains paramount, and this review provides a roadmap for instituting appropriate therapies in cardiovascular disease prevention.
治疗血脂异常仍然是一个充满活力和争议的话题。即使是血脂水平的最适当治疗范围——包括甘油三酯和低密度脂蛋白胆固醇——也仍在积极争论中。此外,随着可供选择的治疗方法越来越多,血脂异常的管理在深度和复杂性上都有了进展。了解适当的降脂治疗仍然是医学各专业医生复习的重要课题。本综述的目的是提供血脂异常患者的最新研究进展和建议的概述,以便更好地为脂质管理的临床实践提供信息。通过采用指南指导的方法,我们在血脂异常的各个方面提供了最佳降脂治疗的参考点。特别关注降脂治疗的长期依从性,以及通过结构化的方式同时监测,适当使用药物所带来的益处。详细讨论了新型治疗方法及其对降脂的影响,以及未来研究的潜在途径。预防心血管疾病仍然至关重要,本综述为实施心血管疾病预防的适当治疗提供了路线图。