Pilch Weronika, Wojturska Wiktoria, Potocki Pawel M
Oncology Department, Faculty of Medicine, Jagiellonian University Medical College, Cracow, POL.
Cureus. 2024 Dec 25;16(12):e76378. doi: 10.7759/cureus.76378. eCollection 2024 Dec.
Gastric cancer is a common type of gastrointestinal tract malignancy. It is characterized by a poor prognosis - median survival for metastatic disease is about 12 months. A small percentage of gastric cancer is characterized by high sensitivity to systemic treatment, resulting in deep and durable responses. Predictors for such hyper-responses are still under investigation, and a wide variety of possible mechanisms exist, including the DNA damage response, intracellular signaling, immune engagement, genetic alterations, and the tumor microenvironment. Here we present a case of a 59-year-old patient with human epidermal growth factor receptor-2 (HER-2)-negative, programmed death ligand-1 (PD-L1) negative, mismatch repair proficient (pMMR) metastatic gastric cancer who reached a particularly long progression-free survival (PFS) exceeding 93 months.
胃癌是一种常见的胃肠道恶性肿瘤。其特点是预后较差——转移性疾病的中位生存期约为12个月。一小部分胃癌对全身治疗高度敏感，可产生深度且持久的反应。此类超敏反应的预测指标仍在研究中，存在多种可能的机制，包括DNA损伤反应、细胞内信号传导、免疫参与、基因改变和肿瘤微环境。在此，我们报告一例59岁的患者，其患有人类表皮生长因子受体2（HER-2）阴性、程序性死亡配体1（PD-L1）阴性、错配修复功能正常（pMMR）的转移性胃癌，其无进展生存期（PFS）特别长，超过了93个月。
