Ledsome J R, Wilson N, Courneya C A
Can J Physiol Pharmacol. 1985 Mar;63(3):224-9. doi: 10.1139/y85-042.
In chloralose-anaesthetized dogs, plasma vasopressin concentration was measured by radioimmunoassay during step changes in blood volume of 4 mL/kg over a range of blood volume from +20 to -12 mL/kg. Blood volume was both increased and decreased over this range. There was a logarithmic relationship between blood volume and plasma vasopressin concentration over the range of blood volume examined. There was also a logarithmic relationship between blood volume and mean left atrial pressure. Linear regression between the natural logarithm of plasma vasopressin concentration and mean arterial pressure, heart rate, and mean left atrial pressure gave the highest correlation coefficient (r = 0.94) between vasopressin and mean arterial pressure. The results support the hypothesis that there are sensitive mechanisms controlling the release of vasopressin in response to changes in blood volume. Observations were also made of changes in atrial pressure and activity of left atrial receptors during changes in blood volume over the same range. The results suggest that changes in atrial receptor activity are unlikely to be the major cause of the large increases in plasma vasopressin concentration associated with hypovolemia.
在水合氯醛麻醉的犬中，通过放射免疫分析法在血容量从 +20 至 -12 mL/kg 的范围内以 4 mL/kg 的步长改变血容量期间测量血浆血管加压素浓度。在此范围内血容量既有增加也有减少。在所检查的血容量范围内，血容量与血浆血管加压素浓度之间存在对数关系。血容量与平均左心房压力之间也存在对数关系。血浆血管加压素浓度的自然对数与平均动脉压、心率和平均左心房压力之间的线性回归得出血管加压素与平均动脉压之间的最高相关系数（r = 0.94）。结果支持这样的假说，即存在敏感机制控制血管加压素的释放以响应血容量的变化。还对在相同范围内血容量变化期间心房压力和左心房受体活性的变化进行了观察。结果表明，心房受体活性的变化不太可能是与血容量减少相关的血浆血管加压素浓度大幅增加的主要原因。
