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用阿达木单抗治疗的化脓性汗腺炎患者中的边缘区淋巴瘤

Marginal Zone Lymphoma in a Case of Hidradenitis Suppurativa Treated With Adalimumab Therapy.

作者信息

Shrestha Anish K, Pokherel Rojina, Gaddipati Greeshma N, Desai Pankti S

机构信息

Department of Internal Medicine, MedStar Health Internal Medicine Residency Program, Baltimore, USA.

Department of Internal Medicine, MedStar Health Franklin Square Medical Center, Baltimore, USA.

出版信息

J Community Hosp Intern Med Perspect. 2025 Jan 6;15(1):58-62. doi: 10.55729/2000-9666.1444. eCollection 2025.

Abstract

Marginal zone lymphoma has seldom been described in relation to adalimumab used for treatment of hidradenitis suppurativa. Although studies have shown an increased risk of lymphoma with adalimumab, most of these studies were done in patients with underlying inflammatory bowel disease or rheumatoid arthritis where the disease itself presents as a confounder for lymphoma. Our case described adds to the role of chronic anti-TNF alpha therapy as a possible etiology of lymphoma.

摘要

关于用于治疗化脓性汗腺炎的阿达木单抗,边缘区淋巴瘤很少被描述。尽管研究表明使用阿达木单抗会增加淋巴瘤风险,但这些研究大多是在患有潜在炎症性肠病或类风湿性关节炎的患者中进行的,在这些疾病中,疾病本身是淋巴瘤的一个混杂因素。我们所描述的病例进一步说明了慢性抗TNF-α治疗可能是淋巴瘤的病因之一。

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