McNeish Brendan L, Miljkovic Iva, Allison Matthew A, Hughes Timothy, Nasrallah Ilya, Terkpertey Eric, Rosano Caterina
medRxiv. 2025 Jan 13:2025.01.12.25320415. doi: 10.1101/2025.01.12.25320415.
Prior research linking myosteatosis with cognition in older adults has been conducted in relatively homogenous populations with narrow age ranges. We evaluated if abdominal myosteatosis was associated with processing speed in a multiethnic cohort of middle aged and older adults.
The analytical sample included 1,268 adults (46-86 years old, mean 63±9 years, 53% female of 41% White, 20% Black, 14% Chinese, and 25% Hispanic), a subset from the Multi-Ethnic Study of Atherosclerosis (MESA). Bivariate analyses were performed between abdominal computed tomography derived muscle densities (a myosteatosis measure) at year 3 with Digit Symbol Coding (DSC) with cytokines. Multivariable models were first adjusted for demographics, education, and general cognition, and further adjusted for other known predictors of dementia: -4, physical activity, diabetes, cholesterol, smoking, and blood pressure. We further assessed whether central adiposity, general adiposity, and cytokines modified this association. We tested interactions by ethnicity, sex, and age.
Rectus abdominis myosteatosis was significantly associated with worse DSC (B= -0.247, 95% CI: 0.098,0.396, p=0.001) independent of demographics, education, general cognition, and dementia risk factors. Adjustment for central adiposity, and cytokines did not attenuate the associations. Tests for interactions by ethnicity, sex, and age were not statistically significant.
Rectus abdominis myosteatosis is associated with worse processing speed in this middle and older aged multiethnic population of men and women, independent of other known predictors of cognition. Longitudinal studies should assess the interplay of myosteatosis with other markers of adiposity, inflammation, and circulating mediators and their combined impact on processing speed.
Abdominal myosteatosis correlated with lower cognitive processing speed in older adults.Myosteatosis links muscle density to cognitive function beyond dementia risk factors.Pro-inflammatory cytokines do not mediate the muscle-cognition association.Ethnicity, sex, and adiposity measures do not modify myosteatosis-cognition links.Abdominal CT scans could serve as diagnostic tools for cognitive health insights.
先前关于老年人肌肉减少性肥胖与认知之间联系的研究是在年龄范围较窄的相对同质人群中进行的。我们评估了在一个多民族的中老年人队列中，腹部肌肉减少性肥胖是否与处理速度有关。
分析样本包括1268名成年人（46 - 86岁，平均63±9岁，53%为女性，41%为白人，20%为黑人，14%为华裔，25%为西班牙裔），是动脉粥样硬化多民族研究（MESA）的一个子集。在第3年时，对腹部计算机断层扫描得出的肌肉密度（一种肌肉减少性肥胖测量指标）与数字符号编码（DSC）及细胞因子进行双变量分析。多变量模型首先针对人口统计学、教育程度和一般认知进行调整，然后进一步针对痴呆的其他已知预测因素进行调整：-4、身体活动、糖尿病、胆固醇、吸烟和血压。我们进一步评估了中心性肥胖、总体肥胖和细胞因子是否会改变这种关联。我们按种族、性别和年龄测试了相互作用。
腹直肌肌肉减少性肥胖与较差的DSC显著相关（B = -0.247，95%置信区间：0.098，0.396，p = 0.001），独立于人口统计学、教育程度、一般认知和痴呆风险因素。对中心性肥胖和细胞因子进行调整并没有减弱这种关联。按种族、性别和年龄进行的相互作用测试无统计学意义。
在这个多民族的中老年男性和女性人群中，腹直肌肌肉减少性肥胖与较差的处理速度有关，独立于其他已知的认知预测因素。纵向研究应评估肌肉减少性肥胖与肥胖、炎症和循环介质的其他标志物之间的相互作用及其对处理速度的综合影响。
腹部肌肉减少性肥胖与老年人较低的认知处理速度相关。肌肉减少性肥胖将肌肉密度与认知功能联系起来，超出了痴呆风险因素。促炎细胞因子不介导肌肉与认知的关联。种族、性别和肥胖测量指标不会改变肌肉减少性肥胖与认知的联系。腹部CT扫描可作为洞察认知健康的诊断工具。
