McNeish Brendan L, Miljkovic Iva, Allison Matthew A, Hughes Timothy, Nasrallah Ilya, Terkpertey Eric, Rosano Caterina
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Arch Gerontol Geriatr. 2025 Jun;133:105823. doi: 10.1016/j.archger.2025.105823. Epub 2025 Mar 8.
Prior research linking myosteatosis with cognition in older adults has been conducted in relatively homogenous populations with narrow age ranges. We evaluated if abdominal myosteatosis was associated with processing speed in a multiethnic cohort of middle aged and older adults.
The sample included 1,268 adults (46-86 years-old, mean 63±9 years, 53 % female, 41 % White, 20 % Black, 14 % Chinese, and 25 % Hispanic), a subset from the Multi-Ethnic Study of Atherosclerosis. Bivariate analyses examined the relationships between abdominal computed tomography-derived muscle density (measure of myosteatosis) at clinical exam 3, Digit Symbol Coding (DSC) performance at clinical exam 5, and cytokine levels from clinical exam 1. Multivariable models were adjusted for demographics, education, general cognition, and further adjusted for other known predictors of dementia: APOE-4, physical activity, diabetes, cholesterol, smoking, and blood pressure. We assessed whether central adiposity, general adiposity, and cytokines modified this association. We tested interactions by ethnicity, sex, and age.
Rectus abdominis myosteatosis was significantly associated with worse DSC (B=-0.247, 95 % CI: 0.098,0.396, p = 0.001) independent of demographics, education, general cognition, and dementia risk factors. Adjustment for central adiposity, and cytokines did not attenuate the associations and interactions by ethnicity, sex, and age were not statistically significant.
Rectus abdominis myosteatosis is associated with worse processing speed in this middle and older aged multiethnic population of men and women, independent of known predictors of cognition. Longitudinal studies should assess the interplay of myosteatosis with other markers of adiposity, inflammation, and circulating mediators and their impact on processing speed.
先前关于老年人肌少脂症与认知之间联系的研究是在年龄范围较窄的相对同质人群中进行的。我们评估了在一个多民族的中老年人群队列中，腹部肌少脂症是否与处理速度相关。
样本包括1268名成年人（46 - 86岁，平均63±9岁，53%为女性，41%为白人，20%为黑人，14%为中国人，25%为西班牙裔），是动脉粥样硬化多民族研究的一个子集。双变量分析检查了临床检查3时腹部计算机断层扫描得出的肌肉密度（肌少脂症的测量指标）、临床检查5时数字符号编码（DSC）表现以及临床检查1时细胞因子水平之间的关系。多变量模型对人口统计学、教育程度、一般认知进行了调整，并进一步对痴呆的其他已知预测因素进行了调整：APOE - 4、身体活动、糖尿病、胆固醇、吸烟和血压。我们评估了中心性肥胖、总体肥胖和细胞因子是否改变了这种关联。我们按种族、性别和年龄测试了相互作用。
腹直肌肌少脂症与较差的DSC显著相关（B = -0.247，95%置信区间：0.098，0.396，p = 0.001），独立于人口统计学、教育程度、一般认知和痴呆风险因素。对中心性肥胖和细胞因子进行调整并没有减弱这种关联，并且按种族、性别和年龄的相互作用在统计学上并不显著。
在这个多民族的中老年男性和女性人群中，腹直肌肌少脂症与较差的处理速度相关，独立于已知的认知预测因素。纵向研究应评估肌少脂症与肥胖、炎症和循环介质的其他标志物之间的相互作用及其对处理速度的影响。
