Schwartz M R, Randolph R L, Panko W B
Cancer. 1985 May 15;55(10):2464-71. doi: 10.1002/1097-0142(19850515)55:10<2464::aid-cncr2820551026>3.0.co;2-w.
Cytosols of 159 primary breast carcinomas were assayed for estrogen and progesterone receptors and 60 of these for carcinoembryonic antigen (CEA). The relationships of pathologic and clinical features previously shown to be of prognostic significance and the biochemical parameter measured were examined. It was found that degree of histologic differentiation was significantly related to receptor status. There were significant inverse relationships between estrogen receptor and lymphocytic infiltrate as well as tumor necrosis. Relationships between estrogen, but not progesterone, receptor and patient age, menstrual status, and race existed. Cytosol CEA, on the other hand, related only to pathologic stage and not to histologic differentiation and other pathologic variables. Therefore, steroid receptors and CEA appear to provide information about different biologic characteristics of a carcinoma. Furthermore, the information provided by CEA appears to be independent of many known pathologic, clinical, and biochemical prognostic indicators.
对159例原发性乳腺癌的细胞溶胶进行雌激素和孕激素受体检测，其中60例检测癌胚抗原（CEA）。研究了先前显示具有预后意义的病理和临床特征与所测生化参数之间的关系。结果发现，组织学分化程度与受体状态显著相关。雌激素受体与淋巴细胞浸润以及肿瘤坏死之间存在显著的负相关。雌激素受体与患者年龄、月经状态和种族之间存在关系，而孕激素受体与这些因素无关。另一方面，细胞溶胶CEA仅与病理分期有关，与组织学分化和其他病理变量无关。因此，类固醇受体和CEA似乎提供了有关癌的不同生物学特征的信息。此外，CEA提供的信息似乎独立于许多已知的病理、临床和生化预后指标。
