Lesser M L, Rosen P P, Senie R T, Duthie K, Menendez-Botet C, Schwartz M K
Cancer. 1981 Jul 15;48(2):299-309. doi: 10.1002/1097-0142(19810715)48:2<299::aid-cncr2820480215>3.0.co;2-2.
Analysis of estrogen receptor protein (ERP) was carried out on 784 patients with primary breast carcinomas. Significant relationships were found with the following epidemiologic features; age at diagnosis, menstrual status, race, and use of exogenous hormones (contraceptive and menopausal estrogens). Patients taking either type of hormone at diagnosis had lower median total ERP binding levels. Although the data do not explain how recent hormone usage affects tumor ERP, it seems advisable to discontinue these hormones as early as possible before a breast biopsy because they may cause spuriously low ERP levels. Correlation with pathology variables confirmed most prior observations relating to tumor type, histologic grade, and lymphocytic infiltrate. However, in this large series, infiltrating lobular carcinomas were not ERP-positive more frequently than duct carcinomas to any significant degree. The pattern of progesterone receptors (PRP) did not vary significantly with menstrual status, but in other respects correlations of epidemiologic and pathologic variables were similar for ERP and PRP.
对784例原发性乳腺癌患者进行了雌激素受体蛋白（ERP）分析。发现其与以下流行病学特征存在显著关联：诊断时的年龄、月经状态、种族以及外源性激素（避孕药和绝经后雌激素）的使用情况。诊断时服用任何一种激素的患者，其ERP总结合水平中位数较低。尽管数据并未解释近期激素使用如何影响肿瘤ERP，但在进行乳房活检前尽早停用这些激素似乎是明智的，因为它们可能导致ERP水平假性降低。与病理变量的相关性证实了大多数先前关于肿瘤类型、组织学分级和淋巴细胞浸润的观察结果。然而，在这个大样本系列中，浸润性小叶癌的ERP阳性率并不比导管癌高到任何显著程度。孕激素受体（PRP）模式在月经状态方面没有显著差异，但在其他方面，ERP和PRP在流行病学和病理变量的相关性上是相似的。
