Liu Yanbin, Yan Jun
Department of Respiratory, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Department of Respiratory, The Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China.
Front Nutr. 2025 Jan 10;11:1526575. doi: 10.3389/fnut.2024.1526575. eCollection 2024.
Vitamin B6 is involved in regulating a variety of biological reactions in cell metabolism, and possesses antioxidant and anti-inflammatory biological functions. 5'-pyridoxal phosphate (PLP) is the main biologically active form of vitamin B6. There is currently no research on the correlation between serum PLP levels and chronic obstructive pulmonary disease (COPD) prevalence. This study aims to explore the relationship between serum PLP levels and COPD prevalence.
This cross-sectional study included adult participants with complete data on COPD diagnosis and serum PLP levels from 2005 to 2010 National Health and Nutrition Examination Survey (NHANES) database. Generalized linear model (GLM) was employed to analyze the association between serum PLP levels and COPD prevalence. The restricted cubic spline (RCS) curve and threshold effect analysis were used to explore the potential non-linear relationship between serum PLP levels and COPD prevalence. Subgroup analysis was carried out to assess the robustness of the relationship between serum PLP levels and COPD prevalence.
A total of 11,103 participants were included in this study, of whom 830 were diagnosed with COPD. Higher PLP levels are associated with a reduced prevalence of COPD. GLM analysis confirmed that the groups with higher PLP levels (Q3 and Q4) had a significantly lower prevalence rate of COPD compared to the group of Q2. The RCS curves showed a non-linear "L"-shaped relationship between serum PLP levels and COPD prevalence. The threshold effect analysis found a critical point of 43.3 nmol/L. When serum PLP level is below 43.3 nmol/L, there is a negative correlation between serum PLP levels and COPD prevalence ( for overall <0.001, for nonlinear <0.001). Subgroup analysis and interaction tests confirmed the robustness of the relationship.
This study is the first to discover a non-linear relationship between serum PLP levels and COPD prevalence. Higher serum PLP levels are associated with a reduced prevalence of COPD.
维生素B6参与调节细胞代谢中的多种生物反应，并具有抗氧化和抗炎生物功能。5'-磷酸吡哆醛（PLP）是维生素B6的主要生物活性形式。目前尚无关于血清PLP水平与慢性阻塞性肺疾病（COPD）患病率之间相关性的研究。本研究旨在探讨血清PLP水平与COPD患病率之间的关系。
这项横断面研究纳入了2005年至2010年国家健康与营养检查调查（NHANES）数据库中具有完整COPD诊断和血清PLP水平数据的成年参与者。采用广义线性模型（GLM）分析血清PLP水平与COPD患病率之间的关联。使用受限立方样条（RCS）曲线和阈值效应分析来探索血清PLP水平与COPD患病率之间潜在的非线性关系。进行亚组分析以评估血清PLP水平与COPD患病率之间关系的稳健性。
本研究共纳入11103名参与者，其中830人被诊断为COPD。较高的PLP水平与较低的COPD患病率相关。GLM分析证实，与Q2组相比，PLP水平较高的组（Q3和Q4）COPD患病率显著较低。RCS曲线显示血清PLP水平与COPD患病率之间呈非线性“L”形关系。阈值效应分析发现临界点为43.3 nmol/L。当血清PLP水平低于43.3 nmol/L时，血清PLP水平与COPD患病率呈负相关（总体<0.001，非线性<0.001）。亚组分析和交互检验证实了这种关系的稳健性。
本研究首次发现血清PLP水平与COPD患病率之间存在非线性关系。较高的血清PLP水平与较低的COPD患病率相关。
